Effects of intraventricular methotrexate on folate, adenosine, and homocysteine metabolism in cerebrospinal fluid

Charles T. Quinn, James C. Griener, Teodoro Bottiglieri, Erland Arning, Naomi J. Winick

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

Methotrexate (MTX) is an antifolate that affects many metabolic pathways. MTX may cause neurologic toxicity, but the biochemical effects of MTX on the central nervous system (CNS) are poorly characterized. The authors studied serial cerebrospinal fluid (CSF) samples from a child during two courses of intraventricular MTX and found a rapid and reproducible depletion in CSF of reduced folates and S-adenosylmethionine that was accompanied by marked increases in homocysteine and adenosine. No sulfur-containing excitatory amino acids were detected. This study demonstrates multiple profound effects of MTX on CNS metabolism and provides insight to the pathogenesis of MTX neurotoxicity.

Original languageEnglish (US)
Pages (from-to)386-388
Number of pages3
JournalJournal of Pediatric Hematology/Oncology
Volume26
Issue number6
DOIs
StatePublished - Jun 2004

Fingerprint

Homocysteine
Folic Acid
Methotrexate
Adenosine
Cerebrospinal Fluid
Central Nervous System
Folic Acid Antagonists
S-Adenosylmethionine
Excitatory Amino Acids
Metabolic Networks and Pathways
Sulfur
Nervous System

Keywords

  • Adenosine
  • Central nervous system
  • Cerebrospinal fluid
  • Folate
  • Homocysteine
  • Methotrexate

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Oncology
  • Hematology

Cite this

Effects of intraventricular methotrexate on folate, adenosine, and homocysteine metabolism in cerebrospinal fluid. / Quinn, Charles T.; Griener, James C.; Bottiglieri, Teodoro; Arning, Erland; Winick, Naomi J.

In: Journal of Pediatric Hematology/Oncology, Vol. 26, No. 6, 06.2004, p. 386-388.

Research output: Contribution to journalArticle

Quinn, Charles T. ; Griener, James C. ; Bottiglieri, Teodoro ; Arning, Erland ; Winick, Naomi J. / Effects of intraventricular methotrexate on folate, adenosine, and homocysteine metabolism in cerebrospinal fluid. In: Journal of Pediatric Hematology/Oncology. 2004 ; Vol. 26, No. 6. pp. 386-388.
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