Effects of lithium on platelet ionic intracellular calcium concentration in patients with bipolar (manic-depressive) disorder and healthy controls

Chay Hoon Tan, Martin A. Javors, Ermias Seleshi, Patricia A. Lowrimore, Charles L. Bowden

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

Lithium is an effective drug in the treatment of both manic and depressive episodes of bipolar disorder. Lithium has been shown to block the metabolism of the intracellular second messenger inositol-1,4,5-trisphosphate which is involved in the rise in ionic intracellular calcium ([Ca++]i) which triggers neurotransmitter release and other cellular changes in secretory cells. We have measured the effect of lithium on [Ca++]i dynamics in platelets from bipolar patients stabilized with lithium treatment, and from healthy controls. Both resting [Ca++]i and the thrombin stimulated increase in [Ca++]i were higher in bipolar patients than in controls. Lithium added in vitro tended to increase the thrombin-stimulated rise in [Ca++]i. The use of the fluorescent Ca++ probe fura-2 in human platelets provides a useful method to investigate the mechanism of lithium's action in bipolar disorder and to study Ca++ related systems which may be abnormal in bipolar disorders.

Original languageEnglish (US)
Pages (from-to)1175-1180
Number of pages6
JournalLife Sciences
Volume46
Issue number16
DOIs
StatePublished - 1990

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Depressive Disorder
Platelets
Bipolar Disorder
Lithium
Blood Platelets
Calcium
Thrombin
Inositol 1,4,5-Trisphosphate
Fura-2
Second Messenger Systems
Fluorescent Dyes
Metabolism
Neurotransmitter Agents
Therapeutics
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Pharmacology

Cite this

Effects of lithium on platelet ionic intracellular calcium concentration in patients with bipolar (manic-depressive) disorder and healthy controls. / Tan, Chay Hoon; Javors, Martin A.; Seleshi, Ermias; Lowrimore, Patricia A.; Bowden, Charles L.

In: Life Sciences, Vol. 46, No. 16, 1990, p. 1175-1180.

Research output: Contribution to journalArticle

Tan, Chay Hoon ; Javors, Martin A. ; Seleshi, Ermias ; Lowrimore, Patricia A. ; Bowden, Charles L. / Effects of lithium on platelet ionic intracellular calcium concentration in patients with bipolar (manic-depressive) disorder and healthy controls. In: Life Sciences. 1990 ; Vol. 46, No. 16. pp. 1175-1180.
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