Effects of m-cholinoceptor antagonists on the neuromuscular junction

E. Olmez, Y. Egilmez, M. O. Guc, M. Ilhan

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The effects of four m-cholinoceptor antagonists and d-tubocurarine on carbachol- or nicotine-induced contractions of frog rectus abdominis muscle were investigated. The n-cholinoceptor-mediated contractile responses of frog rectus abdominis muscle were inhibited competitively by d-tubocurarine whereas m-cholinoceptor antagonists inhibited them noncompetitively. Antagonistic potencies for m-cholinoceptor antagonists, assessed by PD'2 values, indicated a rank order of potency which was 4-DAMP > AF-DX 116 > atropine > pirenzepine. The antagonistic potencies of m-cholinoceptor antagonists on electrically induced twitch responses of rat phrenic nerve-diaphragm preparation were also examined. These responses were blocked by 4-DAMP, but pirenzepine had no effect. However, they were enhanced by AF-DX 116 or atropine. Inhibitory action of 4-DAMP in this preparation was suggested to be due to noncompetitive blockade of postjunctional n-cholinoceptors.

Original languageEnglish (US)
Pages (from-to)52-60
Number of pages9
JournalPharmacology
Volume49
Issue number1
StatePublished - 1994

Fingerprint

Neuromuscular Junction
Cholinergic Receptors
Pirenzepine
Tubocurarine
Rectus Abdominis
Atropine
Anura
Muscles
Phrenic Nerve
Carbachol
Diaphragm
Nicotine
4-diphenylacetoxy-1,1-dimethylpiperidinium

Keywords

  • m-Cholinoceptor antagonists
  • n-Cholinoceptors
  • Neuromuscular junction

ASJC Scopus subject areas

  • Pharmacology

Cite this

Effects of m-cholinoceptor antagonists on the neuromuscular junction. / Olmez, E.; Egilmez, Y.; Guc, M. O.; Ilhan, M.

In: Pharmacology, Vol. 49, No. 1, 1994, p. 52-60.

Research output: Contribution to journalArticle

Olmez, E, Egilmez, Y, Guc, MO & Ilhan, M 1994, 'Effects of m-cholinoceptor antagonists on the neuromuscular junction', Pharmacology, vol. 49, no. 1, pp. 52-60.
Olmez, E. ; Egilmez, Y. ; Guc, M. O. ; Ilhan, M. / Effects of m-cholinoceptor antagonists on the neuromuscular junction. In: Pharmacology. 1994 ; Vol. 49, No. 1. pp. 52-60.
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