Effects of magnesium oxide on the crystallization of calcium salts in urine in patients with recurrent nephrolithiasis

C. D. Fetner, D. E. Barilla, J. Townsend, C. Y C Pak

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

The effect of oral administration of magnesium oxide on the crystallization in urine of calcium oxalate and brushite was determined in 4 cases of recurrent calcium nephrolithiasis. Each patient was evaluated while on a constant metabolic diet before, during and after therapy with magnesium (1,000 mg. magnesium as magnesium oxide per day). During magnesium therapy urinary hydrogen ion concentration increased by approximately 0.5 unit in all 4 patients and urinary calcium increased about 50 mg per day in 2. Urinary oxalate decreased significantly in 1 patient and urinary phosphorus was reduced in 2. The urinary activity product ratio of brushite (state of saturation) increased, owing largely to the rise in urinary hydrogen ion concentration but that of calcium oxalate was not changed significantly by magnesium treatment. Although urinary magnesium increased significantly there was no significant change in the urinary formation product ratio (limit of metastability) or the rate of crystal growth of brushite or calcium oxalate. Thus, no beneficial effect of magnesium therapy could be demonstrated in this short-term study.

Original languageEnglish (US)
Pages (from-to)399-401
Number of pages3
JournalJournal of Urology
Volume120
Issue number4
StatePublished - 1978

Fingerprint

Magnesium Oxide
Nephrolithiasis
Crystallization
Magnesium
Salts
Urine
Calcium
Calcium Oxalate
Oxalates
Therapeutics
Phosphorus
Oral Administration
Diet

ASJC Scopus subject areas

  • Urology

Cite this

Effects of magnesium oxide on the crystallization of calcium salts in urine in patients with recurrent nephrolithiasis. / Fetner, C. D.; Barilla, D. E.; Townsend, J.; Pak, C. Y C.

In: Journal of Urology, Vol. 120, No. 4, 1978, p. 399-401.

Research output: Contribution to journalArticle

@article{83acb81f1bb749baa9c5124c7fef2486,
title = "Effects of magnesium oxide on the crystallization of calcium salts in urine in patients with recurrent nephrolithiasis",
abstract = "The effect of oral administration of magnesium oxide on the crystallization in urine of calcium oxalate and brushite was determined in 4 cases of recurrent calcium nephrolithiasis. Each patient was evaluated while on a constant metabolic diet before, during and after therapy with magnesium (1,000 mg. magnesium as magnesium oxide per day). During magnesium therapy urinary hydrogen ion concentration increased by approximately 0.5 unit in all 4 patients and urinary calcium increased about 50 mg per day in 2. Urinary oxalate decreased significantly in 1 patient and urinary phosphorus was reduced in 2. The urinary activity product ratio of brushite (state of saturation) increased, owing largely to the rise in urinary hydrogen ion concentration but that of calcium oxalate was not changed significantly by magnesium treatment. Although urinary magnesium increased significantly there was no significant change in the urinary formation product ratio (limit of metastability) or the rate of crystal growth of brushite or calcium oxalate. Thus, no beneficial effect of magnesium therapy could be demonstrated in this short-term study.",
author = "Fetner, {C. D.} and Barilla, {D. E.} and J. Townsend and Pak, {C. Y C}",
year = "1978",
language = "English (US)",
volume = "120",
pages = "399--401",
journal = "Journal of Urology",
issn = "0022-5347",
publisher = "Elsevier Inc.",
number = "4",

}

TY - JOUR

T1 - Effects of magnesium oxide on the crystallization of calcium salts in urine in patients with recurrent nephrolithiasis

AU - Fetner, C. D.

AU - Barilla, D. E.

AU - Townsend, J.

AU - Pak, C. Y C

PY - 1978

Y1 - 1978

N2 - The effect of oral administration of magnesium oxide on the crystallization in urine of calcium oxalate and brushite was determined in 4 cases of recurrent calcium nephrolithiasis. Each patient was evaluated while on a constant metabolic diet before, during and after therapy with magnesium (1,000 mg. magnesium as magnesium oxide per day). During magnesium therapy urinary hydrogen ion concentration increased by approximately 0.5 unit in all 4 patients and urinary calcium increased about 50 mg per day in 2. Urinary oxalate decreased significantly in 1 patient and urinary phosphorus was reduced in 2. The urinary activity product ratio of brushite (state of saturation) increased, owing largely to the rise in urinary hydrogen ion concentration but that of calcium oxalate was not changed significantly by magnesium treatment. Although urinary magnesium increased significantly there was no significant change in the urinary formation product ratio (limit of metastability) or the rate of crystal growth of brushite or calcium oxalate. Thus, no beneficial effect of magnesium therapy could be demonstrated in this short-term study.

AB - The effect of oral administration of magnesium oxide on the crystallization in urine of calcium oxalate and brushite was determined in 4 cases of recurrent calcium nephrolithiasis. Each patient was evaluated while on a constant metabolic diet before, during and after therapy with magnesium (1,000 mg. magnesium as magnesium oxide per day). During magnesium therapy urinary hydrogen ion concentration increased by approximately 0.5 unit in all 4 patients and urinary calcium increased about 50 mg per day in 2. Urinary oxalate decreased significantly in 1 patient and urinary phosphorus was reduced in 2. The urinary activity product ratio of brushite (state of saturation) increased, owing largely to the rise in urinary hydrogen ion concentration but that of calcium oxalate was not changed significantly by magnesium treatment. Although urinary magnesium increased significantly there was no significant change in the urinary formation product ratio (limit of metastability) or the rate of crystal growth of brushite or calcium oxalate. Thus, no beneficial effect of magnesium therapy could be demonstrated in this short-term study.

UR - http://www.scopus.com/inward/record.url?scp=0018128655&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018128655&partnerID=8YFLogxK

M3 - Article

VL - 120

SP - 399

EP - 401

JO - Journal of Urology

JF - Journal of Urology

SN - 0022-5347

IS - 4

ER -