Effects of maternal exposure to polychlorobiphenyls (PCBs) on F1 generation behavior in the rat

GianCarlo Pantaleoni, DonaTella Fanini, Anna Maria Sponta, Giancarlo Palumbo, Raffaele Giorgi, Perrie M. Adams

Research output: Contribution to journalArticle

103 Citations (Scopus)

Abstract

The effect of Fenclor 42 (PCB) exposure of female rats (Fischer 344 strain) was studied through assessment of the behavioral development of their F1 progeny. Female rats were exposed to PCB according to the following treatment schedule: (A) (5 days) 2 weeks prior to mating, (B) during gestation (Days 6-15 of pregnancy), (C) during lactation (Days 1-21 after delivery). Behavioral endpoints of motor reflexes, motor coordination, activity (preweaning behaviors), and learning (postweaning behavior) were evaluated for PCB ip dosages of 5-10 mg/kg/day for 5 days (preconception exposure), and PCB oral dosages of 2-4 mg/kg/day for 10 days (in utero exposure) and of 1-2 mg/kg/day for 20 days (during lactation exposure). Dosage-dependent differnces in the evaluated behaviors were found in the offspring of the PCB-exposed females when compared to the offspring of corn-oil (vehicle)-exposed females. Significant differences in the development of cliff avoidance reflexive behavior, swimming ability, and open field activity were particularly evident. Furthermore the PCB exposure of female rats during gestation and lactation resulted in impaired acquisition of the active avoidance behavior while preconceptional PCB exposure significantly affected active avoidance performance as reflected in increased number of avoidance responses to reach criterion for extinction. These results show that Fenclor 42 does possess a significant risk to the offspring of exposed females, and further illustrate the sensitivity of progeny behavioral assessment in detecting suspected functional teratogenesis.

Original languageEnglish (US)
Pages (from-to)440-449
Number of pages10
JournalFundamental and Applied Toxicology
Volume11
Issue number3
DOIs
StatePublished - 1988

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Maternal Exposure
Rats
Lactation
Avoidance Learning
Corn Oil
Pregnancy
Teratogenesis
Aptitude
Inbred F344 Rats
Reflex
Appointments and Schedules
Motor Activity
Learning

ASJC Scopus subject areas

  • Toxicology

Cite this

Effects of maternal exposure to polychlorobiphenyls (PCBs) on F1 generation behavior in the rat. / Pantaleoni, GianCarlo; Fanini, DonaTella; Sponta, Anna Maria; Palumbo, Giancarlo; Giorgi, Raffaele; Adams, Perrie M.

In: Fundamental and Applied Toxicology, Vol. 11, No. 3, 1988, p. 440-449.

Research output: Contribution to journalArticle

Pantaleoni, GianCarlo ; Fanini, DonaTella ; Sponta, Anna Maria ; Palumbo, Giancarlo ; Giorgi, Raffaele ; Adams, Perrie M. / Effects of maternal exposure to polychlorobiphenyls (PCBs) on F1 generation behavior in the rat. In: Fundamental and Applied Toxicology. 1988 ; Vol. 11, No. 3. pp. 440-449.
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