TY - JOUR
T1 - Effects of methotrexate treatment on serum immunoreactivity of a patient with normal-pressure glaucoma
AU - Fellman, Ronald L.
AU - Tezel, Gülgün
AU - Wax, Martin B.
N1 - Funding Information:
This study was supported in part by grant EY12314 (M.B.W.) from National Eye Institute, Bethesda, Maryland; the American Health Assistance Foundation, Washington, DC (M.B.W.); the Glaucoma Research Foundation, San Francisco, California (M.B.W.); and an unrestricted grant from Research to Prevent Blindness, Inc, New York, New York.
Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 1999/6
Y1 - 1999/6
N2 - PURPOSE: Increased serum immunoreactivity to retinal proteins may have a role in the disease process of some glaucoma patients. We describe a patient with normal-pressure glaucoma whose serum immunoreactivity to retinal proteins regressed after methotrexate treatment for rheumatoid disease. METHOD: Case report. RESULTS: In a 66-year-old white female with normal- pressure glaucoma and rheumatoid disease, sequential Western blots using patient sera against retinal proteins demonstrated a decrease in the immunoreactive bands after treatment. During the treatment period of 3 years, her visual fields appeared to have improved. Optic disk examination during the short periods without treatment, however, disclosed new, bilateral splinter hemorrhages on the optic, disks. CONCLUSION: These observations suggest a potential role for immune-based intervention in similar patients.
AB - PURPOSE: Increased serum immunoreactivity to retinal proteins may have a role in the disease process of some glaucoma patients. We describe a patient with normal-pressure glaucoma whose serum immunoreactivity to retinal proteins regressed after methotrexate treatment for rheumatoid disease. METHOD: Case report. RESULTS: In a 66-year-old white female with normal- pressure glaucoma and rheumatoid disease, sequential Western blots using patient sera against retinal proteins demonstrated a decrease in the immunoreactive bands after treatment. During the treatment period of 3 years, her visual fields appeared to have improved. Optic disk examination during the short periods without treatment, however, disclosed new, bilateral splinter hemorrhages on the optic, disks. CONCLUSION: These observations suggest a potential role for immune-based intervention in similar patients.
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U2 - 10.1016/S0002-9394(99)00020-3
DO - 10.1016/S0002-9394(99)00020-3
M3 - Article
C2 - 10372887
AN - SCOPUS:0033030757
SN - 0002-9394
VL - 127
SP - 724
EP - 725
JO - American journal of ophthalmology
JF - American journal of ophthalmology
IS - 6
ER -