Effects of motor cortex modulation and descending inhibitory systems on pain thresholds in healthy subjects

Jay S. Reidler, Mariana E. Mendonca, Marcus B. Santana, Xiaoen Wang, Robert Lenkinski, Andrea F. Motta, Serge Marchand, Lydia Latif, Felipe Fregni

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

Pain modulation can be achieved using neuromodulatory tools that influence various levels of the nervous system. Transcranial direct current stimulation (tDCS), for instance, has been shown to reduce chronic pain when applied to the primary motor cortex. In contrast to this central neuromodulatory technique, diffuse noxious inhibitory controls (DNIC) refers to endogenous analgesic mechanisms that decrease pain following the introduction of heterotopic noxious stimuli. We examined whether combining top-down motor cortex modulation using anodal tDCS with a bottom-up DNIC induction paradigm synergistically increases the threshold at which pain is perceived. The pain thresholds of 15 healthy subjects were assessed before and after administration of active tDCS, sham tDCS, cold-water-induced DNIC, and combined tDCS and DNIC. We found that both tDCS and the DNIC paradigm significantly increased pain thresholds and that these approaches appeared to have additive effects. Increase in pain threshold following active tDCS was positively correlated with baseline N-acetylaspartate in the cingulate cortex and negatively correlated with baseline glutamine levels in the thalamus as measured by magnetic resonance spectroscopy. These results suggest that motor cortex modulation may have a greater analgesic effect when combined with bottom-up neuromodulatory mechanisms, presenting new avenues for modulation of pain using noninvasive neuromodulatory approaches. Perspective: This article demonstrates that both noninvasive motor cortex modulation and a descending noxious inhibitory controls paradigm significantly increase pain thresholds in healthy subjects and appear to have an additive effect when combined. These results suggest that existing pain therapies involving DNIC may be enhanced through combination with noninvasive brain stimulation.

Original languageEnglish (US)
Pages (from-to)450-458
Number of pages9
JournalJournal of Pain
Volume13
Issue number5
DOIs
StatePublished - May 2012

Fingerprint

Diffuse Noxious Inhibitory Control
Pain Threshold
Motor Cortex
Healthy Volunteers
Pain
Analgesics
Gyrus Cinguli
Transcranial Direct Current Stimulation
Glutamine
Thalamus
Chronic Pain
Nervous System
Magnetic Resonance Spectroscopy
Water
Brain

Keywords

  • Brain stimulation
  • conditioned pain modulation
  • descending noxious inhibitory controls
  • magnetic resonance spectroscopy
  • tDCS
  • transcranial direct current stimulation

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine
  • Neurology
  • Clinical Neurology

Cite this

Reidler, J. S., Mendonca, M. E., Santana, M. B., Wang, X., Lenkinski, R., Motta, A. F., ... Fregni, F. (2012). Effects of motor cortex modulation and descending inhibitory systems on pain thresholds in healthy subjects. Journal of Pain, 13(5), 450-458. https://doi.org/10.1016/j.jpain.2012.01.005

Effects of motor cortex modulation and descending inhibitory systems on pain thresholds in healthy subjects. / Reidler, Jay S.; Mendonca, Mariana E.; Santana, Marcus B.; Wang, Xiaoen; Lenkinski, Robert; Motta, Andrea F.; Marchand, Serge; Latif, Lydia; Fregni, Felipe.

In: Journal of Pain, Vol. 13, No. 5, 05.2012, p. 450-458.

Research output: Contribution to journalArticle

Reidler, JS, Mendonca, ME, Santana, MB, Wang, X, Lenkinski, R, Motta, AF, Marchand, S, Latif, L & Fregni, F 2012, 'Effects of motor cortex modulation and descending inhibitory systems on pain thresholds in healthy subjects', Journal of Pain, vol. 13, no. 5, pp. 450-458. https://doi.org/10.1016/j.jpain.2012.01.005
Reidler, Jay S. ; Mendonca, Mariana E. ; Santana, Marcus B. ; Wang, Xiaoen ; Lenkinski, Robert ; Motta, Andrea F. ; Marchand, Serge ; Latif, Lydia ; Fregni, Felipe. / Effects of motor cortex modulation and descending inhibitory systems on pain thresholds in healthy subjects. In: Journal of Pain. 2012 ; Vol. 13, No. 5. pp. 450-458.
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