Effects of multiple daily insulin injections on peripheral glucose disposal in Latin Americans with type 2 diabetes mellitus

Larissa Avilés-Santa, Karin Salinas, Beverley A Huet, Philip Raskin

Research output: Contribution to journalArticle

Abstract

Objective: To evaluate the effects of insulin in multiple daily injections (MDI) on peripheral glucose disposal in Latin American patients with type 2 diabetes. Methods and Results: Ten Latin American patients (four men and six women) with type 2 diabetes between the ages of 32 and 45 years were evaluated. All women were premenopausal and had regular menstrual periods. A hyperinsulinemic-euglycemic clamp procedure was performed at baseline and was repeated approximately 2 years after insulin monotherapy on MDI was initiated. Both genders had comparable baseline anthropometric and laboratory features, including a mean body mass index > 30 kg/m2 and percent body fat > 30%. Baseline percent hemoglobin A1c (HbA1c%) was 9.5 ± 1.5%, and post-intervention HbA1c% was 7.0 ± 1.2%. The peripheral glucose disposal rate at baseline was 4.5 ± 2.2 mg/kg/min fat-free mass and at postintervention was 3.6 ± 2.3 mg/kg/min fat-free mass. Conclusions: Despite a significant improvement in glycemic control, MDI did not seem to increase the insulin-mediated glucose disposal rate. Underlying obesity and increased percent body fat may have been the most counteracting factors on the potential improvement in insulin sensitivity expected with insulin monotherapy.

Original languageEnglish (US)
Pages (from-to)11-17
Number of pages7
JournalJournal of Investigative Medicine
Volume55
Issue number1
DOIs
StatePublished - Jan 2007

Keywords

  • Insulin sensitivity
  • Intensive insulin therapy
  • Latinos
  • Obesity
  • Percent body fat
  • Premenopausal women
  • Type 2 diabetes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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