Effects of naloxone on the cardiovascular responses to muscular contraction in decerebrate cats

Tony G. Waldrop; Gary A. Iwamoto

doi:10.1016/0006-8993(84)91196-X

Effects of naloxone on the cardiovascular responses to muscular contraction in decerebrate cats

Tony G. Waldrop, Gary A. Iwamoto

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

The cardiovascular response to muscular contraction induced by ventral root (L7 and S1) stimulation were studied in unanesthetized decerebrate cats before and after the administration of the opiate antagonist naloxone. Intravenous naloxone (1.0-2.0 mg/kg) did not alter the heart rate or arterial pressure responses to either tetanic or repeated twitch contractions. However, naloxone did increase resting arterial pressure.

Original language	English (US)
Pages (from-to)	152-156
Number of pages	5
Journal	Brain Research
Volume	322
Issue number	1
DOIs	https://doi.org/10.1016/0006-8993(84)91196-X
State	Published - Nov 19 1984

Keywords

arterial pressure
cat
endogenous opiates
heart rate
muscular contraction
naloxone

ASJC Scopus subject areas

General Neuroscience
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/0006-8993(84)91196-X

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AU - Iwamoto, Gary A.

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N2 - The cardiovascular response to muscular contraction induced by ventral root (L7 and S1) stimulation were studied in unanesthetized decerebrate cats before and after the administration of the opiate antagonist naloxone. Intravenous naloxone (1.0-2.0 mg/kg) did not alter the heart rate or arterial pressure responses to either tetanic or repeated twitch contractions. However, naloxone did increase resting arterial pressure.

AB - The cardiovascular response to muscular contraction induced by ventral root (L7 and S1) stimulation were studied in unanesthetized decerebrate cats before and after the administration of the opiate antagonist naloxone. Intravenous naloxone (1.0-2.0 mg/kg) did not alter the heart rate or arterial pressure responses to either tetanic or repeated twitch contractions. However, naloxone did increase resting arterial pressure.

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KW - endogenous opiates

KW - heart rate

KW - muscular contraction

KW - naloxone

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Effects of naloxone on the cardiovascular responses to muscular contraction in decerebrate cats

Abstract

Keywords

ASJC Scopus subject areas

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