Effects of nebulized β2-adrenergic agonists on pulmonary mechanics in anesthetized patients with chronic obstructive pulmonary disease

P. Vichitvejpaisal, S. Kumar, G. P. Joshi, P. F. White

Research output: Contribution to journalArticle

Abstract

We evaluated the effects of nebulized β2-adrenergic agonists on pulmonary mechanics in patients with COPD undergoing peripheral surgery with a standardized general anesthetic technique. Thirty males with COPD were randomized into one of three groups. Group I (control group; n = 10) received nebulized saline 3 ml, Group II (n = 10) received nebulized albuterol (2.5 mg in 3 ml), and Group III (n = 10) received nebulized metaproterenol (15 mg in 3 ml). At 20 min after tracheal intubation, the study drugs were nebulized over 20 min. Datex Capnomac Ultima(TM) monitor was used to measure pulmonary mechanics on a breath-by-breath basis. There was no difference between the three groups with respect to demographic data and preoperative respiratory parameters. A similar degree of DPH occurred with the initiation of mechanical ventilation in all three groups. Patients receiving nebulized bronchodilators (Groups II and III) displayed a significant decrease in DPH and an increase in total dynamic compliance. However, there were no differences in DPH and total dynamic compliance between Groups II and III. We conclude that nebulization of either albuterol or metaproterenol can alleviate DPH resulting from mechanical ventilation in anesthetized patients with COPD.

Original languageEnglish (US)
Pages (from-to)779-784
Number of pages6
JournalJournal of the Medical Association of Thailand
Volume79
Issue number12
StatePublished - 1996

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Adrenergic Agonists
Mechanics
Metaproterenol
Chronic Obstructive Pulmonary Disease
Albuterol
Artificial Respiration
Lung
Compliance
General Anesthetics
Bronchodilator Agents
Intubation
Demography
Control Groups
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Medicine(all)

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Effects of nebulized β2-adrenergic agonists on pulmonary mechanics in anesthetized patients with chronic obstructive pulmonary disease. / Vichitvejpaisal, P.; Kumar, S.; Joshi, G. P.; White, P. F.

In: Journal of the Medical Association of Thailand, Vol. 79, No. 12, 1996, p. 779-784.

Research output: Contribution to journalArticle

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