Effects of neuropeptide Y on the isolated rabbit iris dilator muscle

M. Piccone, J. Littzi, T. Krupin, R. A. Stone, M. Davis, M. B. Wax

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

The effects of neuropeptide Y (NPY) were studied on an in vitro preparation of rabbit iris dilator muscle. NPY by itself (10-11 M to 10-6 M) had no effect on the resting tension or on the maximal electrically-induced response (MER) of the dilator. Phenylphrine (10-9 M to 10-4 M) caused a dose-dependent contraction of the dilator muscle (7.8% to 40.6% of the MER). The addition of NPY 10-6 M enhanced the phenylephrine-induced muscle contraction (8.8% to 76.8% of the MER) without altering the EC50 value (5x10-6 M) of the phenylephrine dose-response curve. These findings support a modulatory role for NPY on the iris dilator muscle.

Original languageEnglish (US)
Pages (from-to)330-332
Number of pages3
JournalInvestigative Ophthalmology and Visual Science
Volume29
Issue number2
StatePublished - 1988

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Neuropeptide Y
Iris
Rabbits
Muscles
Phenylephrine
Muscle Contraction

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Piccone, M., Littzi, J., Krupin, T., Stone, R. A., Davis, M., & Wax, M. B. (1988). Effects of neuropeptide Y on the isolated rabbit iris dilator muscle. Investigative Ophthalmology and Visual Science, 29(2), 330-332.

Effects of neuropeptide Y on the isolated rabbit iris dilator muscle. / Piccone, M.; Littzi, J.; Krupin, T.; Stone, R. A.; Davis, M.; Wax, M. B.

In: Investigative Ophthalmology and Visual Science, Vol. 29, No. 2, 1988, p. 330-332.

Research output: Contribution to journalArticle

Piccone, M, Littzi, J, Krupin, T, Stone, RA, Davis, M & Wax, MB 1988, 'Effects of neuropeptide Y on the isolated rabbit iris dilator muscle', Investigative Ophthalmology and Visual Science, vol. 29, no. 2, pp. 330-332.
Piccone M, Littzi J, Krupin T, Stone RA, Davis M, Wax MB. Effects of neuropeptide Y on the isolated rabbit iris dilator muscle. Investigative Ophthalmology and Visual Science. 1988;29(2):330-332.
Piccone, M. ; Littzi, J. ; Krupin, T. ; Stone, R. A. ; Davis, M. ; Wax, M. B. / Effects of neuropeptide Y on the isolated rabbit iris dilator muscle. In: Investigative Ophthalmology and Visual Science. 1988 ; Vol. 29, No. 2. pp. 330-332.
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