Effects of neuropeptide Y on the isolated rabbit iris dilator muscle

M. Piccone; J. Littzi; T. Krupin; R. A. Stone; M. Davis; M. B. Wax

Effects of neuropeptide Y on the isolated rabbit iris dilator muscle

M. Piccone, J. Littzi, T. Krupin, R. A. Stone, M. Davis, M. B. Wax

Ophthalmology

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

The effects of neuropeptide Y (NPY) were studied on an in vitro preparation of rabbit iris dilator muscle. NPY by itself (10^-11 M to 10^-6 M) had no effect on the resting tension or on the maximal electrically-induced response (MER) of the dilator. Phenylphrine (10^-9 M to 10^-4 M) caused a dose-dependent contraction of the dilator muscle (7.8% to 40.6% of the MER). The addition of NPY 10^-6 M enhanced the phenylephrine-induced muscle contraction (8.8% to 76.8% of the MER) without altering the EC₅₀ value (5x10^-6 M) of the phenylephrine dose-response curve. These findings support a modulatory role for NPY on the iris dilator muscle.

Original language	English (US)
Pages (from-to)	330-332
Number of pages	3
Journal	Investigative Ophthalmology and Visual Science
Volume	29
Issue number	2
State	Published - 1988

ASJC Scopus subject areas

Ophthalmology
Sensory Systems
Cellular and Molecular Neuroscience

Cite this

@article{67a6fbc66ee946a1ba43591988fbbd3b,

title = "Effects of neuropeptide Y on the isolated rabbit iris dilator muscle",

abstract = "The effects of neuropeptide Y (NPY) were studied on an in vitro preparation of rabbit iris dilator muscle. NPY by itself (10-11 M to 10-6 M) had no effect on the resting tension or on the maximal electrically-induced response (MER) of the dilator. Phenylphrine (10-9 M to 10-4 M) caused a dose-dependent contraction of the dilator muscle (7.8% to 40.6% of the MER). The addition of NPY 10-6 M enhanced the phenylephrine-induced muscle contraction (8.8% to 76.8% of the MER) without altering the EC50 value (5x10-6 M) of the phenylephrine dose-response curve. These findings support a modulatory role for NPY on the iris dilator muscle.",

author = "M. Piccone and J. Littzi and T. Krupin and Stone, {R. A.} and M. Davis and Wax, {M. B.}",

year = "1988",

language = "English (US)",

volume = "29",

pages = "330--332",

journal = "Investigative Ophthalmology and Visual Science",

issn = "0146-0404",

publisher = "Association for Research in Vision and Ophthalmology Inc.",

number = "2",

}

TY - JOUR

T1 - Effects of neuropeptide Y on the isolated rabbit iris dilator muscle

AU - Piccone, M.

AU - Littzi, J.

AU - Krupin, T.

AU - Stone, R. A.

AU - Davis, M.

AU - Wax, M. B.

PY - 1988

Y1 - 1988

N2 - The effects of neuropeptide Y (NPY) were studied on an in vitro preparation of rabbit iris dilator muscle. NPY by itself (10-11 M to 10-6 M) had no effect on the resting tension or on the maximal electrically-induced response (MER) of the dilator. Phenylphrine (10-9 M to 10-4 M) caused a dose-dependent contraction of the dilator muscle (7.8% to 40.6% of the MER). The addition of NPY 10-6 M enhanced the phenylephrine-induced muscle contraction (8.8% to 76.8% of the MER) without altering the EC50 value (5x10-6 M) of the phenylephrine dose-response curve. These findings support a modulatory role for NPY on the iris dilator muscle.

AB - The effects of neuropeptide Y (NPY) were studied on an in vitro preparation of rabbit iris dilator muscle. NPY by itself (10-11 M to 10-6 M) had no effect on the resting tension or on the maximal electrically-induced response (MER) of the dilator. Phenylphrine (10-9 M to 10-4 M) caused a dose-dependent contraction of the dilator muscle (7.8% to 40.6% of the MER). The addition of NPY 10-6 M enhanced the phenylephrine-induced muscle contraction (8.8% to 76.8% of the MER) without altering the EC50 value (5x10-6 M) of the phenylephrine dose-response curve. These findings support a modulatory role for NPY on the iris dilator muscle.

UR - http://www.scopus.com/inward/record.url?scp=0023837090&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023837090&partnerID=8YFLogxK

M3 - Article

C2 - 3338892

AN - SCOPUS:0023837090

SN - 0146-0404

VL - 29

SP - 330

EP - 332

JO - Investigative Ophthalmology and Visual Science

JF - Investigative Ophthalmology and Visual Science

IS - 2

ER -

Effects of neuropeptide Y on the isolated rabbit iris dilator muscle

Abstract

ASJC Scopus subject areas

Other files and links

Fingerprint

Cite this