Effects of nitroglycerin on cardiac function and regional blood flow distribution in conscious dogs.

S. F. Vatner, M. Pagani, J. D. Rutherford, R. W. Millard, W. T. Manders

Research output: Contribution to journalArticle

Abstract

The effects of intravenous infusion of nitroglycerin (NTG), 8 and 32 microgram/kg.min for 7 min, and of sublingual NTG, 1.2 mg, were examined on direct and continuous measurements of systemic, coronary, and regional hemodynamics, left ventricular (LV) dimensions, pressures, and myocardial contractility in conscious dogs. NTG induced sustained reductions in LV dimensions and transient increases in heart rate and dP/dt, and decreases in mean arterial pressure. Initially NTG increased cardiac output and flows to the coronary, mesenteric, renal, and iliac beds, while systemic and regional vascular resistances fell. Later, cardiac output, cardiac work, and mesenteric and iliac flows fell significantly below control, and significant vasoconstriction in the systemic as well as mesenteric, iliac, and coronary beds was observed at a time when LV end-diastolic dimensions were still significantly reduced. Peripheral vasoconstriction was not observed with systemic NTG in deafferented dogs or when NTG, 1 microgram/kg.min, was infused intra-arterially into the iliac bed. Thus, systemic NTG induces a biphasic response consisting of initial arteriolar vasodilation followed by vasoconstriction in the mesenteric, iliac, coronary and systemic beds, which is presumably due to longer lasting effects on preload and to secondary reflex responses to the drug.

Original languageEnglish (US)
JournalThe American journal of physiology
Volume234
Issue number3
StatePublished - Mar 1978

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Regional Blood Flow
Nitroglycerin
Dogs
Vasoconstriction
Cardiac Output
Ventricular Pressure
Intravenous Infusions
Vasodilation
Vascular Resistance
Reflex
Arterial Pressure
Heart Rate
Hemodynamics
Kidney
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Effects of nitroglycerin on cardiac function and regional blood flow distribution in conscious dogs. / Vatner, S. F.; Pagani, M.; Rutherford, J. D.; Millard, R. W.; Manders, W. T.

In: The American journal of physiology, Vol. 234, No. 3, 03.1978.

Research output: Contribution to journalArticle

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