Effects of oral contraceptives on natriuretic peptide levels in women with hypothalamic amenorrhea: A pilot study

Eleanor Lin, Steven Grinspoon, Thomas Wang, Karen K. Miller

Research output: Contribution to journalArticle

Abstract

Natriuretic peptides, which are important regulators of salt handling and blood pressure, are 60%-75% higher in healthy young women than in men, consistent with a gender dimorphism. In this randomized, placebo-controlled study in women with functional hypothalamic amenorrhea, we show that administration of oral contraceptives (OC) increases natriuretic peptide levels and that end-of-study free T levels are inversely associated with amino-terminal pro-B-type natriuretic peptide levels, consistent with the hypothesis that natriuretic peptide levels may be mediated by differences in gonadal steroid concentrations - estrogens (E) or androgens.

Original languageEnglish (US)
Pages (from-to)2605-2607
Number of pages3
JournalFertility and sterility
Volume95
Issue number8
DOIs
StatePublished - Jun 30 2011
Externally publishedYes

Keywords

  • androgens
  • Natriuretic peptides
  • oral contraceptives

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology

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