Effects of Otic Drops on Chinchilla Tympanic Membrane

M. Masaki, C. G. Wright, D. H. Lee, W. L. Meyerhoff

Research output: Contribution to journalArticlepeer-review

25 Scopus citations


Experimental studies have shown that if antibiotic otic drops reach the middle ear cavity they produce severe inflammation. However, the effects of these preparations on the tympanic membrane have not been thoroughly investigated. This study was designed to assess morphological changes in the chinchilla tympanic membrane two to 21 days after a single 0.2-mL application of an antibiotic otic preparation (Cortisporin Otic Suspension) to the middle ear cavity. At two days, the epidermal and the mucosal layers were destroyed. By four days, reepithelialization had occurred and all layers of the tympanic membrane subsequently became markedly hyperplastic. Disruption of the fibrous layer, invasion of keratinizing epidermis to the medial surface, and perforation were observed at three weeks. These findings indicate that tympanic membrane damage is a potentially significant aspect of the ototoxic properties of topical otic preparations.

Original languageEnglish (US)
Pages (from-to)1007-1011
Number of pages5
JournalArchives of Otolaryngology--Head and Neck Surgery
Issue number9
StatePublished - Sep 1988

ASJC Scopus subject areas

  • Surgery
  • Otorhinolaryngology


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