Effects of partial neuromuscular blockade on carotid baroreflex function during exercise in humans

K. M. Gallagher, P. J. Fadel, M. Strømstad, K. Ide, S. A. Smith, R. G. Querry, P. B. Raven, N. H. Secher

Research output: Contribution to journalArticle

74 Citations (Scopus)

Abstract

1 This investigation was designed to determine the contribution of central command to the resetting of the carotid baroreflex during static and dynamic exercise in humans. 2. Thirteen subjects performed 3.5 min of static one-legged exercise (20% maximal voluntary contraction) and 7 min dynamic cycling (20% maximal oxygen uptake) under two conditions: control (no intervention) and with partial neuromuscular blockade (to increase central command influence) using Norcuron (curare). Carotid baroreflex function was determined at rest and during steady-state exercise using a rapid neck pressure/neck suction technique. Whole-body Norcuron was repeatedly administered to effectively reduce hand-grip strength by approximately 50% of control. 3. Partial neuromuscular blockade increased heart rate, mean arterial pressure, perceived exertion, lactate concentration and plasma noradrenaline concentration during both static and dynamic exercise when compared to control (P<0.05). No effect was seen at rest. Carotid baroreflex resetting was augmented from control static and dynamic exercise by partial neuromuscular blockade without alterations in gain (P<0.05). In addition, the operating point of the reflex was relocated away from the centring point (i.e. closer to threshold) during exercise by partial neuromuscular blockade (P<0.05). 4. These findings suggest that central command actively resets the carotid baroreflex during dynamic and static exercise.

Original languageEnglish (US)
Pages (from-to)861-870
Number of pages10
JournalJournal of Physiology
Volume533
Issue number3
DOIs
StatePublished - Jun 15 2001

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Neuromuscular Blockade
Baroreflex
Vecuronium Bromide
Hand Strength
Neck
Curare
Suction
Reflex
Lactic Acid
Norepinephrine
Arterial Pressure
Heart Rate
Oxygen
Pressure

ASJC Scopus subject areas

  • Physiology

Cite this

Effects of partial neuromuscular blockade on carotid baroreflex function during exercise in humans. / Gallagher, K. M.; Fadel, P. J.; Strømstad, M.; Ide, K.; Smith, S. A.; Querry, R. G.; Raven, P. B.; Secher, N. H.

In: Journal of Physiology, Vol. 533, No. 3, 15.06.2001, p. 861-870.

Research output: Contribution to journalArticle

Gallagher, K. M. ; Fadel, P. J. ; Strømstad, M. ; Ide, K. ; Smith, S. A. ; Querry, R. G. ; Raven, P. B. ; Secher, N. H. / Effects of partial neuromuscular blockade on carotid baroreflex function during exercise in humans. In: Journal of Physiology. 2001 ; Vol. 533, No. 3. pp. 861-870.
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