Effects of paternal ethylene dibromide exposure on F1 generation behavior in the rat

Donatella Fanini, Marvin S. Legator, Perrie M. Adams

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

The effects of ethylene dibromide (EDB) exposure to the male rat were studied through behavioral assessments of their F1 progeny. Exposed males were bred with untreated female rats at 4 or 9 weeks after 5 daily EDB treatments. Behavioral assessment of motor reflexes and motor coordination were examined up to 21 days of age. Significant differences in the development of motor coordination and motor activity were observed in the F1 progeny of EDB-exposed males. These results support the evidence of EDB genototixicity and further demonstrates the utility of behavioral end-points of the offspring as a sensitive means of assessing paternal reproductive risk.

Original languageEnglish (US)
Pages (from-to)133-138
Number of pages6
JournalMutation Research Letters
Volume139
Issue number3
DOIs
StatePublished - Mar 1984

ASJC Scopus subject areas

  • Medicine(all)

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