Effects of paternal ethylene dibromide exposure on F1 generation behavior in the rat

Donatella Fanini; Marvin S. Legator; Perrie M. Adams

doi:10.1016/0165-7992(84)90008-3

Effects of paternal ethylene dibromide exposure on F₁ generation behavior in the rat

Donatella Fanini, Marvin S. Legator, Perrie M. Adams

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

The effects of ethylene dibromide (EDB) exposure to the male rat were studied through behavioral assessments of their F₁ progeny. Exposed males were bred with untreated female rats at 4 or 9 weeks after 5 daily EDB treatments. Behavioral assessment of motor reflexes and motor coordination were examined up to 21 days of age. Significant differences in the development of motor coordination and motor activity were observed in the F₁ progeny of EDB-exposed males. These results support the evidence of EDB genototixicity and further demonstrates the utility of behavioral end-points of the offspring as a sensitive means of assessing paternal reproductive risk.

Original language	English (US)
Pages (from-to)	133-138
Number of pages	6
Journal	Mutation Research Letters
Volume	139
Issue number	3
DOIs	https://doi.org/10.1016/0165-7992(84)90008-3
State	Published - Mar 1984

ASJC Scopus subject areas

General Medicine

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10.1016/0165-7992(84)90008-3

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title = "Effects of paternal ethylene dibromide exposure on F1 generation behavior in the rat",

abstract = "The effects of ethylene dibromide (EDB) exposure to the male rat were studied through behavioral assessments of their F1 progeny. Exposed males were bred with untreated female rats at 4 or 9 weeks after 5 daily EDB treatments. Behavioral assessment of motor reflexes and motor coordination were examined up to 21 days of age. Significant differences in the development of motor coordination and motor activity were observed in the F1 progeny of EDB-exposed males. These results support the evidence of EDB genototixicity and further demonstrates the utility of behavioral end-points of the offspring as a sensitive means of assessing paternal reproductive risk.",

author = "Donatella Fanini and Legator, {Marvin S.} and Adams, {Perrie M.}",

note = "Funding Information: This research was supported by NIOSH grant OH 01245. The authors would like to thank Ms. Carolyn J. Holt for her excellent assistance in preparation of this manuscript, Ms. Sing-Ling Luh, Mr. Peter Mancillas and Mr. Bruce Baily for technical assistance. Parts of this paper were presented at the annual meeting of the Behavioral Teratology Society at Atlantic City in June 1983.",

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doi = "10.1016/0165-7992(84)90008-3",

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journal = "Mutation Research Letters",

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T1 - Effects of paternal ethylene dibromide exposure on F1 generation behavior in the rat

AU - Fanini, Donatella

AU - Legator, Marvin S.

AU - Adams, Perrie M.

N1 - Funding Information: This research was supported by NIOSH grant OH 01245. The authors would like to thank Ms. Carolyn J. Holt for her excellent assistance in preparation of this manuscript, Ms. Sing-Ling Luh, Mr. Peter Mancillas and Mr. Bruce Baily for technical assistance. Parts of this paper were presented at the annual meeting of the Behavioral Teratology Society at Atlantic City in June 1983.

PY - 1984/3

Y1 - 1984/3

N2 - The effects of ethylene dibromide (EDB) exposure to the male rat were studied through behavioral assessments of their F1 progeny. Exposed males were bred with untreated female rats at 4 or 9 weeks after 5 daily EDB treatments. Behavioral assessment of motor reflexes and motor coordination were examined up to 21 days of age. Significant differences in the development of motor coordination and motor activity were observed in the F1 progeny of EDB-exposed males. These results support the evidence of EDB genototixicity and further demonstrates the utility of behavioral end-points of the offspring as a sensitive means of assessing paternal reproductive risk.

AB - The effects of ethylene dibromide (EDB) exposure to the male rat were studied through behavioral assessments of their F1 progeny. Exposed males were bred with untreated female rats at 4 or 9 weeks after 5 daily EDB treatments. Behavioral assessment of motor reflexes and motor coordination were examined up to 21 days of age. Significant differences in the development of motor coordination and motor activity were observed in the F1 progeny of EDB-exposed males. These results support the evidence of EDB genototixicity and further demonstrates the utility of behavioral end-points of the offspring as a sensitive means of assessing paternal reproductive risk.

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Effects of paternal ethylene dibromide exposure on F₁ generation behavior in the rat

Abstract

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