Effects of preeclampsia on maternal and cord blood clotting activity

C. D. Lox, R. A. Word, J. J. Corrigan

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

This study was undertaken to evaluate the effect of preeclampsia on maternal and cord blood clotting parameters. Pregnant controls and preeclamptics plus their offspring had plasma activity for prothrombin time, partial thromboplastin time, fibrinogen, and clotting activity for factors II, VII, VIII, IX, X, XII, plus factor II antigen. Maternal data was consistent with that previously reported by numerous authors. The cord blood data showed that neonates of the preeclamptic mother had elevated fibrinogen and decreased II, V and VII activity, plus decreased II antigen. The data indicates that abnormal clotting parameters seen in the neonates from preeclampic mothers may result from impaired liver function and not as previously thought, from a deficiency in neonatal vitamin K.

Original languageEnglish (US)
Pages (from-to)279-282
Number of pages4
JournalAmerican Journal of Perinatology
Volume2
Issue number4
StatePublished - 1985

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Prothrombin
Blood Coagulation
Pre-Eclampsia
Fetal Blood
Fibrinogen
Mothers
Antigens
Factor VII
Blood Coagulation Factors
Partial Thromboplastin Time
Vitamin K
Prothrombin Time
Liver

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Pediatrics, Perinatology, and Child Health

Cite this

Effects of preeclampsia on maternal and cord blood clotting activity. / Lox, C. D.; Word, R. A.; Corrigan, J. J.

In: American Journal of Perinatology, Vol. 2, No. 4, 1985, p. 279-282.

Research output: Contribution to journalArticle

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