Effects of ranitidine and metoclopramide on gastric fluid ph and volume in children

S. Christensen, A. Farrow-gillespie, J. Lerman

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

To determine the effects of ranitidine and metoclopramide on gastric fluid in children, 40 healthy children (aged 2-8 yr) were allocated randomly to groups of 10 to receive one of four oral premedications 4 h before surgery: no premedication, metoclopramide 0.1 mg kg-1 ranitidine 2 mg kg-1 and metoclopramide 0.1 mg kg-1 with ranitidine 2mg kg-1. After tracheal intubation, gastric fluid was aspirated and analysed for pH and total fluid volume. Ranitidine, with or without metoclopramide, increased gastric fluid pH significantly compared with control (P < 0.05). Gastric fluid volume did not change significantly.

Original languageEnglish (US)
Pages (from-to)456-460
Number of pages5
JournalBritish Journal of Anaesthesia
Volume65
Issue number4
DOIs
StatePublished - Oct 1990

Keywords

  • Anaesthesia: paediatric
  • Gastrointestinal tract: gastric fluid volume, gastric pH
  • Premedication: metoclopramide, ranitidine

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

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