TY - JOUR
T1 - Effects of ranitidine and metoclopramide on gastric fluid ph and volume in children
AU - Christensen, S.
AU - Farrow-gillespie, A.
AU - Lerman, J.
N1 - Funding Information:
Supported in part by a grant from Glaxo Canada Inc.
PY - 1990/10
Y1 - 1990/10
N2 - To determine the effects of ranitidine and metoclopramide on gastric fluid in children, 40 healthy children (aged 2-8 yr) were allocated randomly to groups of 10 to receive one of four oral premedications 4 h before surgery: no premedication, metoclopramide 0.1 mg kg-1 ranitidine 2 mg kg-1 and metoclopramide 0.1 mg kg-1 with ranitidine 2mg kg-1. After tracheal intubation, gastric fluid was aspirated and analysed for pH and total fluid volume. Ranitidine, with or without metoclopramide, increased gastric fluid pH significantly compared with control (P < 0.05). Gastric fluid volume did not change significantly.
AB - To determine the effects of ranitidine and metoclopramide on gastric fluid in children, 40 healthy children (aged 2-8 yr) were allocated randomly to groups of 10 to receive one of four oral premedications 4 h before surgery: no premedication, metoclopramide 0.1 mg kg-1 ranitidine 2 mg kg-1 and metoclopramide 0.1 mg kg-1 with ranitidine 2mg kg-1. After tracheal intubation, gastric fluid was aspirated and analysed for pH and total fluid volume. Ranitidine, with or without metoclopramide, increased gastric fluid pH significantly compared with control (P < 0.05). Gastric fluid volume did not change significantly.
KW - Anaesthesia: paediatric
KW - Gastrointestinal tract: gastric fluid volume, gastric pH
KW - Premedication: metoclopramide, ranitidine
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U2 - 10.1093/bja/65.4.456
DO - 10.1093/bja/65.4.456
M3 - Article
C2 - 2248813
AN - SCOPUS:0025037331
SN - 0007-0912
VL - 65
SP - 456
EP - 460
JO - British Journal of Anaesthesia
JF - British Journal of Anaesthesia
IS - 4
ER -