Effects of retinoids on regulatory cellular interactions in primary mixed lymphocyte reaction (MLR)

Igor M. Dozmorov, Soo Young Lee, Kun Choon Park

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

The effects of two retinoids, all-trans-retinoic acid and 13-cis-retinoic acid on murine splenic lymphocyte proliferative response in mixed culture were evaluated. In contrast with previously reported absence of retinoic acid (RA) effect on mixed lymphocyte reaction (MLR) the conditions for a strong potentiation of proliferative response of murine lymphocyes with RA were obtained. Stimulatory cells were determined to be the main targets for RA. The data suggest that the RA potentiating effect is the result of an increase in stimulator cell immunogenicity after their pre-treatment with RA before use in MLR. Optimal potentiation by retinoids of proliferative response was found at non-optimal conditions of mixed culture.

Original languageEnglish (US)
Pages (from-to)665-685
Number of pages21
JournalImmunopharmacology and Immunotoxicology
Volume17
Issue number4
DOIs
StatePublished - Jan 1 1995

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Toxicology
  • Pharmacology

Fingerprint Dive into the research topics of 'Effects of retinoids on regulatory cellular interactions in primary mixed lymphocyte reaction (MLR)'. Together they form a unique fingerprint.

  • Cite this