Effects of rifampin on biliary lipids in humans

K. Von Bergmann, J. Fierer, H. Y I Mok, Scott M Grundy

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Because the action of rifampin induces hepatic microsomal enzymes, a study was carried out in four patients to determine whether this drug alters the composition of biliary lipids. Several different measurements were made while patients were both on and off rifampin therapy for various infective processes. These measurements included multiple determinations of lipid composition of gallbladder bile, the relative proportions of individual bile acids, and kinetics of cholic acid and chenodeoxycholic acid. In all four patients, the saturation of gallbladder bile increased during rifampin treatment, and the bile consistently became supersaturated. The relative portions of chenodeoxycholic acid and cholic acid were essentially unchanged by treatment, but total synthesis of bile acids increased in three tested patients with rifampin therapy. These results indicate that rifampin increases saturation of bile with cholesterol, but this increase is not due to a reduction in bile acid production.

Original languageEnglish (US)
Pages (from-to)342-345
Number of pages4
JournalAntimicrobial agents and chemotherapy
Volume19
Issue number2
DOIs
StatePublished - 1981

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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