Effects of Sedentary Aging and Lifelong Exercise on Left Ventricular Systolic Function

Erin J. Howden, Graeme Carrick-Ranson, Satyam Sarma, Michinari Hieda, Naoki Fujimoto, Benjamin D. Levine

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Purpose The current study examined whether age-related changes in left ventricular (LV) longitudinal systolic function is an adaptation to a more sedentary lifestyle and can be preserved by lifelong exercise training. Methods A cross-sectional examination of 18 sedentary young (37 ± 6 yr), 29 sedentary seniors (71 ± 5 yr, 0-3 exercise sessions per week), and 26 seniors (68 ± 5 yr) who had performed a committed level (four to seven exercise sessions per week) of lifelong (>25 yr) exercise. Invasive right heart catheterization (pulmonary capillary wedge pressure) and noninvasive measures of LV function were collected at the following conditions: 1) supine rest, 2) during LV unloading (lower body negative pressure), and 3) LV loading (saline infusion). Ejection fraction and preload-recruitable stroke work (PRSW) were used to describe global LV systolic function, while peak systolic tissue velocity and longitudinal strain (LS) indicate LV longitudinal systolic function. To adjust LS for aging and training-related differences in LV preload and afterload, LV end-diastolic volume and end-systolic pressure (ESP) were included as covariates in ANCOVA models. Results Ejection fraction and PRSW were unaffected by aging or lifelong exercise (P = 0.22, P = 0.08, respectively). Peak systolic tissue velocities decreased with aging (P < 0.001) and sedentary seniors had a smaller LS compared with young (P = 0.023) and lifelong exercisers (P = 0.046). Preload-recruitable stroke work, ESP as a covariate did not alter group differences; however, LV end-diastolic volume eliminated group differences between senior groups. Longitudinal strain was preload dependent (P < 0.001), which was independent of aging and lifelong exercise. Conclusions Sedentary aging leads to a reduction in systolic LS, which is attenuated by committed lifelong exercise due to improved LV diastolic filling.

Original languageEnglish (US)
Pages (from-to)494-501
Number of pages8
JournalMedicine and Science in Sports and Exercise
Volume50
Issue number3
DOIs
StatePublished - Mar 1 2018

Fingerprint

Left Ventricular Function
Stroke
Stroke Volume
Lower Body Negative Pressure
Blood Pressure
Sedentary Lifestyle
Pulmonary Wedge Pressure
Cardiac Catheterization
Exercise

Keywords

  • ECHOCARDIOGRAPHY
  • HEALTHY
  • SEDENTARY
  • SPECKLE TRACKING

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Effects of Sedentary Aging and Lifelong Exercise on Left Ventricular Systolic Function. / Howden, Erin J.; Carrick-Ranson, Graeme; Sarma, Satyam; Hieda, Michinari; Fujimoto, Naoki; Levine, Benjamin D.

In: Medicine and Science in Sports and Exercise, Vol. 50, No. 3, 01.03.2018, p. 494-501.

Research output: Contribution to journalArticle

Howden, Erin J. ; Carrick-Ranson, Graeme ; Sarma, Satyam ; Hieda, Michinari ; Fujimoto, Naoki ; Levine, Benjamin D. / Effects of Sedentary Aging and Lifelong Exercise on Left Ventricular Systolic Function. In: Medicine and Science in Sports and Exercise. 2018 ; Vol. 50, No. 3. pp. 494-501.
@article{97d24e93c81c4679b4855fa8c69b5a53,
title = "Effects of Sedentary Aging and Lifelong Exercise on Left Ventricular Systolic Function",
abstract = "Purpose The current study examined whether age-related changes in left ventricular (LV) longitudinal systolic function is an adaptation to a more sedentary lifestyle and can be preserved by lifelong exercise training. Methods A cross-sectional examination of 18 sedentary young (37 ± 6 yr), 29 sedentary seniors (71 ± 5 yr, 0-3 exercise sessions per week), and 26 seniors (68 ± 5 yr) who had performed a committed level (four to seven exercise sessions per week) of lifelong (>25 yr) exercise. Invasive right heart catheterization (pulmonary capillary wedge pressure) and noninvasive measures of LV function were collected at the following conditions: 1) supine rest, 2) during LV unloading (lower body negative pressure), and 3) LV loading (saline infusion). Ejection fraction and preload-recruitable stroke work (PRSW) were used to describe global LV systolic function, while peak systolic tissue velocity and longitudinal strain (LS) indicate LV longitudinal systolic function. To adjust LS for aging and training-related differences in LV preload and afterload, LV end-diastolic volume and end-systolic pressure (ESP) were included as covariates in ANCOVA models. Results Ejection fraction and PRSW were unaffected by aging or lifelong exercise (P = 0.22, P = 0.08, respectively). Peak systolic tissue velocities decreased with aging (P < 0.001) and sedentary seniors had a smaller LS compared with young (P = 0.023) and lifelong exercisers (P = 0.046). Preload-recruitable stroke work, ESP as a covariate did not alter group differences; however, LV end-diastolic volume eliminated group differences between senior groups. Longitudinal strain was preload dependent (P < 0.001), which was independent of aging and lifelong exercise. Conclusions Sedentary aging leads to a reduction in systolic LS, which is attenuated by committed lifelong exercise due to improved LV diastolic filling.",
keywords = "ECHOCARDIOGRAPHY, HEALTHY, SEDENTARY, SPECKLE TRACKING",
author = "Howden, {Erin J.} and Graeme Carrick-Ranson and Satyam Sarma and Michinari Hieda and Naoki Fujimoto and Levine, {Benjamin D.}",
year = "2018",
month = "3",
day = "1",
doi = "10.1249/MSS.0000000000001464",
language = "English (US)",
volume = "50",
pages = "494--501",
journal = "Medicine and Science in Sports and Exercise",
issn = "0195-9131",
publisher = "Lippincott Williams and Wilkins",
number = "3",

}

TY - JOUR

T1 - Effects of Sedentary Aging and Lifelong Exercise on Left Ventricular Systolic Function

AU - Howden, Erin J.

AU - Carrick-Ranson, Graeme

AU - Sarma, Satyam

AU - Hieda, Michinari

AU - Fujimoto, Naoki

AU - Levine, Benjamin D.

PY - 2018/3/1

Y1 - 2018/3/1

N2 - Purpose The current study examined whether age-related changes in left ventricular (LV) longitudinal systolic function is an adaptation to a more sedentary lifestyle and can be preserved by lifelong exercise training. Methods A cross-sectional examination of 18 sedentary young (37 ± 6 yr), 29 sedentary seniors (71 ± 5 yr, 0-3 exercise sessions per week), and 26 seniors (68 ± 5 yr) who had performed a committed level (four to seven exercise sessions per week) of lifelong (>25 yr) exercise. Invasive right heart catheterization (pulmonary capillary wedge pressure) and noninvasive measures of LV function were collected at the following conditions: 1) supine rest, 2) during LV unloading (lower body negative pressure), and 3) LV loading (saline infusion). Ejection fraction and preload-recruitable stroke work (PRSW) were used to describe global LV systolic function, while peak systolic tissue velocity and longitudinal strain (LS) indicate LV longitudinal systolic function. To adjust LS for aging and training-related differences in LV preload and afterload, LV end-diastolic volume and end-systolic pressure (ESP) were included as covariates in ANCOVA models. Results Ejection fraction and PRSW were unaffected by aging or lifelong exercise (P = 0.22, P = 0.08, respectively). Peak systolic tissue velocities decreased with aging (P < 0.001) and sedentary seniors had a smaller LS compared with young (P = 0.023) and lifelong exercisers (P = 0.046). Preload-recruitable stroke work, ESP as a covariate did not alter group differences; however, LV end-diastolic volume eliminated group differences between senior groups. Longitudinal strain was preload dependent (P < 0.001), which was independent of aging and lifelong exercise. Conclusions Sedentary aging leads to a reduction in systolic LS, which is attenuated by committed lifelong exercise due to improved LV diastolic filling.

AB - Purpose The current study examined whether age-related changes in left ventricular (LV) longitudinal systolic function is an adaptation to a more sedentary lifestyle and can be preserved by lifelong exercise training. Methods A cross-sectional examination of 18 sedentary young (37 ± 6 yr), 29 sedentary seniors (71 ± 5 yr, 0-3 exercise sessions per week), and 26 seniors (68 ± 5 yr) who had performed a committed level (four to seven exercise sessions per week) of lifelong (>25 yr) exercise. Invasive right heart catheterization (pulmonary capillary wedge pressure) and noninvasive measures of LV function were collected at the following conditions: 1) supine rest, 2) during LV unloading (lower body negative pressure), and 3) LV loading (saline infusion). Ejection fraction and preload-recruitable stroke work (PRSW) were used to describe global LV systolic function, while peak systolic tissue velocity and longitudinal strain (LS) indicate LV longitudinal systolic function. To adjust LS for aging and training-related differences in LV preload and afterload, LV end-diastolic volume and end-systolic pressure (ESP) were included as covariates in ANCOVA models. Results Ejection fraction and PRSW were unaffected by aging or lifelong exercise (P = 0.22, P = 0.08, respectively). Peak systolic tissue velocities decreased with aging (P < 0.001) and sedentary seniors had a smaller LS compared with young (P = 0.023) and lifelong exercisers (P = 0.046). Preload-recruitable stroke work, ESP as a covariate did not alter group differences; however, LV end-diastolic volume eliminated group differences between senior groups. Longitudinal strain was preload dependent (P < 0.001), which was independent of aging and lifelong exercise. Conclusions Sedentary aging leads to a reduction in systolic LS, which is attenuated by committed lifelong exercise due to improved LV diastolic filling.

KW - ECHOCARDIOGRAPHY

KW - HEALTHY

KW - SEDENTARY

KW - SPECKLE TRACKING

UR - http://www.scopus.com/inward/record.url?scp=85042368216&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85042368216&partnerID=8YFLogxK

U2 - 10.1249/MSS.0000000000001464

DO - 10.1249/MSS.0000000000001464

M3 - Article

C2 - 29077636

AN - SCOPUS:85042368216

VL - 50

SP - 494

EP - 501

JO - Medicine and Science in Sports and Exercise

JF - Medicine and Science in Sports and Exercise

SN - 0195-9131

IS - 3

ER -