Effects of splenectomy and Sendai virus infection on rejection of male skin isografts by pathogen-free C57BL/6 female mice

J. W. Streilein, J. A. Shadduck, S. P. Pakes

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Using C57BL/6 female mice raised under pathogen-free conditions, it was confirmed that splenectomy prior to grafting promotes brisk rejection of male skin isografts. These mice were then used to examine the influence infection with Sendai virus might have on this phenomenon. It was found that Sendai virus infection of skin graft donors renders the grafts prepared there from highly susceptible to the rejection process. Sendai virus infection of female recipients of male isografts had a trivial effect on the ability of these females to reject their test grafts. However, if Sendai-infected females had their spleens removed 7 days before grafting, they exhibited a markedly accelerated rejection process. These studies indicate that viral epizootics within a murine colony, especially if unsuspected, may confuse the accurate interpretation of experimental skin grafting data.

Original languageEnglish (US)
Pages (from-to)34-37
Number of pages4
JournalTransplantation
Volume32
Issue number1
StatePublished - 1981

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Isografts
Sendai virus
Splenectomy
Virus Diseases
Skin
Transplants
Skin Transplantation
Spleen
Infection

ASJC Scopus subject areas

  • Immunology
  • Transplantation

Cite this

Effects of splenectomy and Sendai virus infection on rejection of male skin isografts by pathogen-free C57BL/6 female mice. / Streilein, J. W.; Shadduck, J. A.; Pakes, S. P.

In: Transplantation, Vol. 32, No. 1, 1981, p. 34-37.

Research output: Contribution to journalArticle

Streilein, J. W. ; Shadduck, J. A. ; Pakes, S. P. / Effects of splenectomy and Sendai virus infection on rejection of male skin isografts by pathogen-free C57BL/6 female mice. In: Transplantation. 1981 ; Vol. 32, No. 1. pp. 34-37.
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