Effects of systemically administered cholecystokinin-octapeptide on local cerebral metabolism

Giovanni Lucignani, Linda J. Porrino, Carol A. Tamminga

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

The effects of systemically administered cholecystokinin-octapeptide on local cerebral glucose utilization in rats were studied by means of the 2-[14 C]deoxyglucose method. Decreases in cerebral glucose utilization were observed in discrete regions of the cerebral cortex, mesencephalon, and brainstem, including the lateral habenula, ventral tegmental area, substantia nigra pars compacta, and the nucleus of the solitary tract. These data demonstrate changes in metabolic activity in specific cerebral regions following systemic cholecystokinin administration.

Original languageEnglish (US)
Pages (from-to)147-151
Number of pages5
JournalEuropean Journal of Pharmacology
Volume101
Issue number1-2
DOIs
StatePublished - May 18 1984

Fingerprint

Sincalide
Habenula
Glucose
Ventral Tegmental Area
Solitary Nucleus
Cholecystokinin
Deoxyglucose
Mesencephalon
Cerebral Cortex
Brain Stem
Pars Compacta

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

Cite this

Effects of systemically administered cholecystokinin-octapeptide on local cerebral metabolism. / Lucignani, Giovanni; Porrino, Linda J.; Tamminga, Carol A.

In: European Journal of Pharmacology, Vol. 101, No. 1-2, 18.05.1984, p. 147-151.

Research output: Contribution to journalArticle

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