Effects of vaginal conjugated equine estrogens and ospemifene on the rat vaginal wall and lower urinary tract

P. Antonio Maldonado, T. Ignacio Montoya, Jesus F. Acevedo, Patrick W. Keller, R. Ann Word

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Although the positive effects of vaginal estrogens and the selective estrogen receptor modulator, ospemifene (OS), on the vaginal epithelium are well recognized, less is known regarding the effects of these therapies on the lower urinary tract or vaginal muscularis. Clinical evidence suggests that vaginally administered estrogenmay improve overactive bladder-related symptoms. The objective of this study was to compare the effects of OS, vaginal conjugated equine estrogens (CEE), or both on the vaginal wall and lower urinary tract in a rat model of menopause. Contractile force of the bladder neck, dome, and external urethral sphincter at optimal field stimulation did not differ significantly among treatment groups. Pharmacologic responses to atropine, carbachol, and potassium chloride were similar among groups. Vaginal epithelial thickness and differentiation were differentially regulated by CEE or OS. Ospemifene altered epithelial differentiation pathways in vaginal epithelium in a unique way, and these effects were additive with local CEE. Unless contraindicated, the beneficial effects of vaginal CEE on the vaginal wall outweigh those of OS.

Original languageEnglish (US)
Article number143461
Pages (from-to)81-92
Number of pages12
JournalBiology of reproduction
Volume96
Issue number1
DOIs
StatePublished - Jan 1 2017

Keywords

  • Bladder
  • Estrogen
  • Menopause
  • Premarin
  • SERMs
  • Urethra
  • Vagina
  • Vulvovaginal atrophy

ASJC Scopus subject areas

  • Reproductive Medicine
  • Cell Biology

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