Effects of vasopressin on multiple fixed-ratio fixed-interval schedules of reinforcement

Steven L. Cohen, Martha Knight, Carol A. Tamminga, Thomas N. Chase

Research output: Contribution to journalArticle

Abstract

The effect of arginine- and des-glycinamide arginine vasopressin on steady-state operant responding was examined. Rats were trained to press a lever for food under a multiple fixed-interval 4-min fixed-ratio 30 schedule of reinforcement. Arg vasopressin (0.5 to 100μg/kg, subcutaneous) produced a dose-dependent decrease in response rate, but des-glycinamide arginine vasopressin (0.5 to l00μg/kg, subcutaneous) had no effect. Neither peptide significantly altered fixed-interval response patterning. These data suggest that vasopressin’s behavioral effects should be viewed in light of its aversive peripheral actions.

Original languageEnglish (US)
Pages (from-to)531-534
Number of pages4
JournalBulletin of the Psychonomic Society
Volume23
Issue number6
DOIs
StatePublished - 1985

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Arginine
Arginine Vasopressin
Vasopressins
Reinforcement
Peptides
Rats
glycine amide

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

Cite this

Effects of vasopressin on multiple fixed-ratio fixed-interval schedules of reinforcement. / Cohen, Steven L.; Knight, Martha; Tamminga, Carol A.; Chase, Thomas N.

In: Bulletin of the Psychonomic Society, Vol. 23, No. 6, 1985, p. 531-534.

Research output: Contribution to journalArticle

Cohen, Steven L. ; Knight, Martha ; Tamminga, Carol A. ; Chase, Thomas N. / Effects of vasopressin on multiple fixed-ratio fixed-interval schedules of reinforcement. In: Bulletin of the Psychonomic Society. 1985 ; Vol. 23, No. 6. pp. 531-534.
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