Effects of Zoxazolamine and Related Centrally Acting Muscle Relaxants on Nigrostriatal Dopaminergic Neurons

R. T. Matthews, B. A. McMillen, S. G. Speciale, H. Jarrah, P. A. Shore, M. K. Sanghera, P. D. Shepard, D. C. German

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

The effects of zoxazolamine (ZOX) and related centrally acting muscle relaxants on striatal dopamine (DA) metabolism and turnover, and substantia nigra zona compacta DA neuronal impulse flow were studied in rats. ZOX, chlorzoxazone and mephenesin, but not meprobamate, chloral hydrate, diazepam, pentobarbital, ethanol or dantrolene, decreased striatal DA metabolism without affecting striatal DA concentrations. More specifically, ZOX, as a representative muscle relaxant, was shown to decrease striatal DA turnover without directly affecting DA synthesis, catabolism, reuptake, or release. ZOX decreased nigral DA neuronal firing rates and dramatically decreased firing rate variability (normally many of the cells fire with bursting firing patterns but after ZOX the cells often fired with a very regular pacemaker-like firing pattern). ZOX and related centrally acting muscle relaxants appear to decrease striatal DA turnover by decreasing both neuronal firing rate and firing rate variability. The possible relationships between DA neuronal activity and muscle tone are discussed.

Original languageEnglish (US)
Pages (from-to)479-486
Number of pages8
JournalBrain Research Bulletin
Volume12
Issue number5
DOIs
StatePublished - May 1984

Keywords

  • Centrally acting muscle relaxants
  • Dopamine
  • Dopaminergic neurons
  • Substantia nigra
  • Zoxazolamine

ASJC Scopus subject areas

  • Neuroscience(all)

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    Matthews, R. T., McMillen, B. A., Speciale, S. G., Jarrah, H., Shore, P. A., Sanghera, M. K., Shepard, P. D., & German, D. C. (1984). Effects of Zoxazolamine and Related Centrally Acting Muscle Relaxants on Nigrostriatal Dopaminergic Neurons. Brain Research Bulletin, 12(5), 479-486. https://doi.org/10.1016/0361-9230(84)90163-1