Effects of Zoxazolamine and Related Centrally Acting Muscle Relaxants on Nigrostriatal Dopaminergic Neurons

R. T. Matthews, B. A. McMillen, S. G. Speciale, H. Jarrah, P. A. Shore, M. K. Sanghera, P. D. Shepard, D. C. German

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

The effects of zoxazolamine (ZOX) and related centrally acting muscle relaxants on striatal dopamine (DA) metabolism and turnover, and substantia nigra zona compacta DA neuronal impulse flow were studied in rats. ZOX, chlorzoxazone and mephenesin, but not meprobamate, chloral hydrate, diazepam, pentobarbital, ethanol or dantrolene, decreased striatal DA metabolism without affecting striatal DA concentrations. More specifically, ZOX, as a representative muscle relaxant, was shown to decrease striatal DA turnover without directly affecting DA synthesis, catabolism, reuptake, or release. ZOX decreased nigral DA neuronal firing rates and dramatically decreased firing rate variability (normally many of the cells fire with bursting firing patterns but after ZOX the cells often fired with a very regular pacemaker-like firing pattern). ZOX and related centrally acting muscle relaxants appear to decrease striatal DA turnover by decreasing both neuronal firing rate and firing rate variability. The possible relationships between DA neuronal activity and muscle tone are discussed.

Original languageEnglish (US)
Pages (from-to)479-486
Number of pages8
JournalBrain Research Bulletin
Volume12
Issue number5
DOIs
StatePublished - 1984

Fingerprint

Zoxazolamine
Central Muscle Relaxants
Dopaminergic Neurons
Dopamine
Corpus Striatum
Mephenesin
Chlorzoxazone
Meprobamate
Chloral Hydrate
Dantrolene
Muscles
Herpes Zoster
Substantia Nigra
Pentobarbital
Diazepam
Ethanol

Keywords

  • Centrally acting muscle relaxants
  • Dopamine
  • Dopaminergic neurons
  • Substantia nigra
  • Zoxazolamine

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Effects of Zoxazolamine and Related Centrally Acting Muscle Relaxants on Nigrostriatal Dopaminergic Neurons. / Matthews, R. T.; McMillen, B. A.; Speciale, S. G.; Jarrah, H.; Shore, P. A.; Sanghera, M. K.; Shepard, P. D.; German, D. C.

In: Brain Research Bulletin, Vol. 12, No. 5, 1984, p. 479-486.

Research output: Contribution to journalArticle

Matthews, RT, McMillen, BA, Speciale, SG, Jarrah, H, Shore, PA, Sanghera, MK, Shepard, PD & German, DC 1984, 'Effects of Zoxazolamine and Related Centrally Acting Muscle Relaxants on Nigrostriatal Dopaminergic Neurons', Brain Research Bulletin, vol. 12, no. 5, pp. 479-486. https://doi.org/10.1016/0361-9230(84)90163-1
Matthews, R. T. ; McMillen, B. A. ; Speciale, S. G. ; Jarrah, H. ; Shore, P. A. ; Sanghera, M. K. ; Shepard, P. D. ; German, D. C. / Effects of Zoxazolamine and Related Centrally Acting Muscle Relaxants on Nigrostriatal Dopaminergic Neurons. In: Brain Research Bulletin. 1984 ; Vol. 12, No. 5. pp. 479-486.
@article{33ea14eccf3b4452974bcf45842028ec,
title = "Effects of Zoxazolamine and Related Centrally Acting Muscle Relaxants on Nigrostriatal Dopaminergic Neurons",
abstract = "The effects of zoxazolamine (ZOX) and related centrally acting muscle relaxants on striatal dopamine (DA) metabolism and turnover, and substantia nigra zona compacta DA neuronal impulse flow were studied in rats. ZOX, chlorzoxazone and mephenesin, but not meprobamate, chloral hydrate, diazepam, pentobarbital, ethanol or dantrolene, decreased striatal DA metabolism without affecting striatal DA concentrations. More specifically, ZOX, as a representative muscle relaxant, was shown to decrease striatal DA turnover without directly affecting DA synthesis, catabolism, reuptake, or release. ZOX decreased nigral DA neuronal firing rates and dramatically decreased firing rate variability (normally many of the cells fire with bursting firing patterns but after ZOX the cells often fired with a very regular pacemaker-like firing pattern). ZOX and related centrally acting muscle relaxants appear to decrease striatal DA turnover by decreasing both neuronal firing rate and firing rate variability. The possible relationships between DA neuronal activity and muscle tone are discussed.",
keywords = "Centrally acting muscle relaxants, Dopamine, Dopaminergic neurons, Substantia nigra, Zoxazolamine",
author = "Matthews, {R. T.} and McMillen, {B. A.} and Speciale, {S. G.} and H. Jarrah and Shore, {P. A.} and Sanghera, {M. K.} and Shepard, {P. D.} and German, {D. C.}",
year = "1984",
doi = "10.1016/0361-9230(84)90163-1",
language = "English (US)",
volume = "12",
pages = "479--486",
journal = "Brain Research Bulletin",
issn = "0361-9230",
publisher = "Elsevier Inc.",
number = "5",

}

TY - JOUR

T1 - Effects of Zoxazolamine and Related Centrally Acting Muscle Relaxants on Nigrostriatal Dopaminergic Neurons

AU - Matthews, R. T.

AU - McMillen, B. A.

AU - Speciale, S. G.

AU - Jarrah, H.

AU - Shore, P. A.

AU - Sanghera, M. K.

AU - Shepard, P. D.

AU - German, D. C.

PY - 1984

Y1 - 1984

N2 - The effects of zoxazolamine (ZOX) and related centrally acting muscle relaxants on striatal dopamine (DA) metabolism and turnover, and substantia nigra zona compacta DA neuronal impulse flow were studied in rats. ZOX, chlorzoxazone and mephenesin, but not meprobamate, chloral hydrate, diazepam, pentobarbital, ethanol or dantrolene, decreased striatal DA metabolism without affecting striatal DA concentrations. More specifically, ZOX, as a representative muscle relaxant, was shown to decrease striatal DA turnover without directly affecting DA synthesis, catabolism, reuptake, or release. ZOX decreased nigral DA neuronal firing rates and dramatically decreased firing rate variability (normally many of the cells fire with bursting firing patterns but after ZOX the cells often fired with a very regular pacemaker-like firing pattern). ZOX and related centrally acting muscle relaxants appear to decrease striatal DA turnover by decreasing both neuronal firing rate and firing rate variability. The possible relationships between DA neuronal activity and muscle tone are discussed.

AB - The effects of zoxazolamine (ZOX) and related centrally acting muscle relaxants on striatal dopamine (DA) metabolism and turnover, and substantia nigra zona compacta DA neuronal impulse flow were studied in rats. ZOX, chlorzoxazone and mephenesin, but not meprobamate, chloral hydrate, diazepam, pentobarbital, ethanol or dantrolene, decreased striatal DA metabolism without affecting striatal DA concentrations. More specifically, ZOX, as a representative muscle relaxant, was shown to decrease striatal DA turnover without directly affecting DA synthesis, catabolism, reuptake, or release. ZOX decreased nigral DA neuronal firing rates and dramatically decreased firing rate variability (normally many of the cells fire with bursting firing patterns but after ZOX the cells often fired with a very regular pacemaker-like firing pattern). ZOX and related centrally acting muscle relaxants appear to decrease striatal DA turnover by decreasing both neuronal firing rate and firing rate variability. The possible relationships between DA neuronal activity and muscle tone are discussed.

KW - Centrally acting muscle relaxants

KW - Dopamine

KW - Dopaminergic neurons

KW - Substantia nigra

KW - Zoxazolamine

UR - http://www.scopus.com/inward/record.url?scp=0021273156&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021273156&partnerID=8YFLogxK

U2 - 10.1016/0361-9230(84)90163-1

DO - 10.1016/0361-9230(84)90163-1

M3 - Article

C2 - 6467036

AN - SCOPUS:0021273156

VL - 12

SP - 479

EP - 486

JO - Brain Research Bulletin

JF - Brain Research Bulletin

SN - 0361-9230

IS - 5

ER -