Effects of137Cs γ irradiation on cognitive performance and measures of anxiety in Apoe-/- and wild-type female mice

Summer F. Acevedo, Gwendolyn McGinnis, Jacob Raber

Research output: Contribution to journalArticle

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Abstract

Mice deficient in apoE (Apoe-/-) can be used to assess the potential role of apoE in the effects of cranial irradiation on hippocampal function. Radiation-induced impairments in hippocampal function may be more pronounced in female Apoe-/- mice and more pronounced in mice irradiated and tested cognitively later in life. To assess this possibility, female wild-type and Apoe-/- mice were irradiated at 6 months of age with 10 Gy 137Cs γ rays and tested cognitively 3 months later. Sham-irradiated wild-type female mice showed enhanced hippocampal-dependent novel location recognition compared to sham-irradiated Apoe-/- female mice. However, cranial irradiation impaired novel location recognition similarly in both genotypes. Cranial irradiation also impaired hippocampal-dependent spatial memory retention similarly in wild-type and Apoe-/- female mice in the water maze. Because novel location recognition was not affected after 137Cs γ irradiation in younger mice, these data support the possibility that older mice are more susceptible to the effects of γ radiation on novel location recognition. Together with the impairments in spatial memory retention in the water maze after irradiation, these data support the existence of detrimental effects of cranial irradiation on hippocampal function. In addition, compared to wild-type female mice, Apoe-/- female mice showed enhanced levels of anxiety, and in Apoe-/-, but not in wild-type, female mice, radiation decreased levels of anxiety. Because levels of anxiety during the hidden session of the water maze were associated with ability to locate the hidden platform, assessments of anxiety need to be considered in evaluating the effects of cranial irradiation on cognitive performance after cranial irradiation.

Original languageEnglish (US)
Pages (from-to)422-428
Number of pages7
JournalRadiation Research
Volume170
Issue number4
DOIs
StatePublished - Oct 2008

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anxiety
Apolipoproteins E
mice
Anxiety
Cranial Irradiation
irradiation
impairment
Water
radiation
Radiation
water
Aptitude
Needs Assessment
Radiation Effects

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Biophysics
  • Radiation

Cite this

Effects of137Cs γ irradiation on cognitive performance and measures of anxiety in Apoe-/- and wild-type female mice. / Acevedo, Summer F.; McGinnis, Gwendolyn; Raber, Jacob.

In: Radiation Research, Vol. 170, No. 4, 10.2008, p. 422-428.

Research output: Contribution to journalArticle

Acevedo, Summer F. ; McGinnis, Gwendolyn ; Raber, Jacob. / Effects of137Cs γ irradiation on cognitive performance and measures of anxiety in Apoe-/- and wild-type female mice. In: Radiation Research. 2008 ; Vol. 170, No. 4. pp. 422-428.
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