Efficacy and Safety of Monoclonal Antibody to Human Tumor Necrosis Factor α in Patients With Sepsis Syndrome: A Randomized, Controlled, Double-blind, Multicenter Clinical Trial

Edward Abraham, Richard Wunderink, Henry Silverman, Trish M. Perl, Richard P. Wenzel, Stanley Nasraway, Howard Levy, Robert Balk, Randy Allred, James E. Pennington, Janice C. Wherry, Roger Bone

Research output: Contribution to journalArticle

708 Citations (Scopus)
Original languageEnglish (US)
Pages (from-to)934-941
Number of pages8
JournalJAMA: The Journal of the American Medical Association
Volume273
Issue number12
DOIs
StatePublished - Mar 22 1995

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Systemic Inflammatory Response Syndrome
APACHE
Survival Analysis
Septic Shock
Double-Blind Method
Intravenous Infusions
Multicenter Studies
Cause of Death
Analysis of Variance
Tumor Necrosis Factor-alpha
Monoclonal Antibodies
Clinical Trials
Prospective Studies
Safety
human TNF protein

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Efficacy and Safety of Monoclonal Antibody to Human Tumor Necrosis Factor α in Patients With Sepsis Syndrome : A Randomized, Controlled, Double-blind, Multicenter Clinical Trial. / Abraham, Edward; Wunderink, Richard; Silverman, Henry; Perl, Trish M.; Wenzel, Richard P.; Nasraway, Stanley; Levy, Howard; Balk, Robert; Allred, Randy; Pennington, James E.; Wherry, Janice C.; Bone, Roger.

In: JAMA: The Journal of the American Medical Association, Vol. 273, No. 12, 22.03.1995, p. 934-941.

Research output: Contribution to journalArticle

Abraham, Edward ; Wunderink, Richard ; Silverman, Henry ; Perl, Trish M. ; Wenzel, Richard P. ; Nasraway, Stanley ; Levy, Howard ; Balk, Robert ; Allred, Randy ; Pennington, James E. ; Wherry, Janice C. ; Bone, Roger. / Efficacy and Safety of Monoclonal Antibody to Human Tumor Necrosis Factor α in Patients With Sepsis Syndrome : A Randomized, Controlled, Double-blind, Multicenter Clinical Trial. In: JAMA: The Journal of the American Medical Association. 1995 ; Vol. 273, No. 12. pp. 934-941.
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