TY - JOUR
T1 - Efficacy of dialectical behavior therapy for adolescents at high risk for suicide a randomized clinical trial
AU - McCauley, Elizabeth
AU - Berk, Michele S.
AU - Asarnow, Joan R.
AU - Adrian, Molly
AU - Cohen, Judith
AU - Korslund, Kathyrn
AU - Avina, Claudia
AU - Hughes, Jennifer
AU - Harned, Melanie
AU - Gallop, Robert
AU - Linehan, Marsha M.
N1 - Funding Information:
Funding/Support: The study was funded by grants 5R01MH090159 (Drs Linehan and McCauley, principal investigators at University of Washington, Seattle Children’s Hospital) and R01MH93898 (Drs Berk and Asarnow, principal investigators at Los Angeles sites) from the NIMH.
Funding Information:
Berk, Asarnow, Adrian, Cohen, Korslund, Hughes, and Avina reported receiving grant support from the National Institute of Mental Health (NIMH), National Institutes of Health. Dr Asarnow reported receiving grant support and support from the Substance Abuse and Mental Health Services Administration, American Foundation for Suicide Prevention, American Psychological Association, and the Society of Clinical Child and Adolescent Psychology and serving as a consultant on quality improvement interventions for depression and suicidal/self-harm behavior. Dr Harned reported receiving grant support and personal fees from the Behavioral Tech LLC outside the work represented in this article. Dr Linehan reported receiving royalties from Guilford Press for books that she has written on dialectical behavior therapy, royalties for training materials from Behavioral Tech LLC, and compensation for dialectical behavior therapy workshops, online programs, and books. No other disclosures were reported.
Publisher Copyright:
© 2018 American Medical Association. All rights reserved.
PY - 2018/8
Y1 - 2018/8
N2 - OBJECTIVE To evaluate the efficacy of dialectical behavior therapy (DBT) compared with individual and group supportive therapy (IGST) for reducing suicide attempts, nonsuicidal self-injury, and overall self-harm among high-risk youths. DESIGN, SETTING, AND PARTICIPANTS This randomized clinical trial was conducted from January 1, 2012, through August 31, 2014, at 4 academic medical centers. A total of 173 participants (pool of 195; 22 withdrew or were excluded) 12 to 18 years of age with a prior lifetime suicide attempt (3 prior self-harm episodes, suicidal ideation, or emotional dysregulation) were studied. Adaptive randomization balanced participants across conditions within sites based on age, number of prior suicide attempts, and psychotropic medication use. Participants were followed up for 1 year. INTERVENTIONS Study participants were randomly assigned to DBT or IGST. Treatment duration was 6 months. Both groups had weekly individual and group psychotherapy, therapist consultation meetings, and parent contact as needed. MAIN OUTCOMES AND MEASURES A priori planned outcomes were suicide attempts, nonsuicidal self-injury, and total self-harm assessed using the Suicide Attempt Self-Injury Interview. RESULTS A total of 173 adolescents (163 [94.8%] female and 97 [56.4%] white; mean [SD] age, 14.89 [1.47] years) were studied. Significant advantages were found for DBT on all primary outcomes after treatment: suicide attempts (65 [90.3%] of 72 receiving DBT vs 51 [78.9%] of 65 receiving IGST with no suicide attempts; odds ratio [OR], 0.30; 95% CI, 0.10-0.91), nonsuicidal self-injury (41 [56.9%] of 72 receiving DBT vs 26 [40.0%] of 65 receiving IGST with no self-injury; OR, 0.32; 95% CI, 0.13-0.70), and self-harm (39 [54.2%] of 72 receiving DBT vs 24 [36.9%] of 65 receiving IGST with no self-harm; OR, 0.33; 95% CI, 0.14-0.78). Rates of self-harm decreased through 1-year follow-up. The advantage of DBT decreased, with no statistically significant between-group differences from 6 to 12 months (OR, 0.65; 95% CI, 0.12-3.36; P = .61). Treatment completion rates were higher for DBT (75.6%) than for IGST (55.2%), but pattern-mixture models indicated that this difference did not informatively affect outcomes. CONCLUSIONS AND RELEVANCE The results of this trial support the efficacy of DBT for reducing self-harm and suicide attempts in highly suicidal self-harming adolescents. On the basis of the criteria of 2 independent trials supporting efficacy, results support DBT as the first well-established, empirically supported treatment for decreasing repeated suicide attempts and self-harm in youths.
AB - OBJECTIVE To evaluate the efficacy of dialectical behavior therapy (DBT) compared with individual and group supportive therapy (IGST) for reducing suicide attempts, nonsuicidal self-injury, and overall self-harm among high-risk youths. DESIGN, SETTING, AND PARTICIPANTS This randomized clinical trial was conducted from January 1, 2012, through August 31, 2014, at 4 academic medical centers. A total of 173 participants (pool of 195; 22 withdrew or were excluded) 12 to 18 years of age with a prior lifetime suicide attempt (3 prior self-harm episodes, suicidal ideation, or emotional dysregulation) were studied. Adaptive randomization balanced participants across conditions within sites based on age, number of prior suicide attempts, and psychotropic medication use. Participants were followed up for 1 year. INTERVENTIONS Study participants were randomly assigned to DBT or IGST. Treatment duration was 6 months. Both groups had weekly individual and group psychotherapy, therapist consultation meetings, and parent contact as needed. MAIN OUTCOMES AND MEASURES A priori planned outcomes were suicide attempts, nonsuicidal self-injury, and total self-harm assessed using the Suicide Attempt Self-Injury Interview. RESULTS A total of 173 adolescents (163 [94.8%] female and 97 [56.4%] white; mean [SD] age, 14.89 [1.47] years) were studied. Significant advantages were found for DBT on all primary outcomes after treatment: suicide attempts (65 [90.3%] of 72 receiving DBT vs 51 [78.9%] of 65 receiving IGST with no suicide attempts; odds ratio [OR], 0.30; 95% CI, 0.10-0.91), nonsuicidal self-injury (41 [56.9%] of 72 receiving DBT vs 26 [40.0%] of 65 receiving IGST with no self-injury; OR, 0.32; 95% CI, 0.13-0.70), and self-harm (39 [54.2%] of 72 receiving DBT vs 24 [36.9%] of 65 receiving IGST with no self-harm; OR, 0.33; 95% CI, 0.14-0.78). Rates of self-harm decreased through 1-year follow-up. The advantage of DBT decreased, with no statistically significant between-group differences from 6 to 12 months (OR, 0.65; 95% CI, 0.12-3.36; P = .61). Treatment completion rates were higher for DBT (75.6%) than for IGST (55.2%), but pattern-mixture models indicated that this difference did not informatively affect outcomes. CONCLUSIONS AND RELEVANCE The results of this trial support the efficacy of DBT for reducing self-harm and suicide attempts in highly suicidal self-harming adolescents. On the basis of the criteria of 2 independent trials supporting efficacy, results support DBT as the first well-established, empirically supported treatment for decreasing repeated suicide attempts and self-harm in youths.
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U2 - 10.1001/jamapsychiatry.2018.1109
DO - 10.1001/jamapsychiatry.2018.1109
M3 - Article
C2 - 29926087
AN - SCOPUS:85051029934
SN - 2168-622X
VL - 75
SP - 777
EP - 785
JO - JAMA Psychiatry
JF - JAMA Psychiatry
IS - 8
ER -