TY - JOUR
T1 - Efficacy of esketamine augmentation in major depressive disorder
T2 - A meta-analysis
AU - Papakostas, George I.
AU - Salloum, Naji C.
AU - Hock, Rebecca S.
AU - Jha, Manish K.
AU - Murrough, James W.
AU - Mathew, Sanjay J.
AU - Iosifescu, Dan V.
AU - Fava, Maurizio
N1 - Publisher Copyright:
© 2020 Copyright Physicians Postgraduate Press, Inc.
PY - 2020/8
Y1 - 2020/8
N2 - Objective: Esketamine, the S-enantiomer of ketamine, was recently approved as a rapid-acting intranasal therapy for depression and is currently under development for suicidality. The authors sought to determine the efficacy of adjunctive intranasal esketamine in major depressive disorder (MDD). Data Sources: A systematic search of PubMed/MEDLINE was conducted up to January 2019, in addition to abstracts of major psychiatric meetings held since 2010. Searches were conducted by cross-referencing the term intranasal with the term esketamine. Where necessary, authors and/or study sponsors were contacted in order to obtain a copy of the presentation as well as any pertinent study details. Study Selection: 241 study abstracts were initially identified and reviewed. Selected studies were randomized, double-blind clinical trials comparing adjunctive intranasal esketamine to adjunctive placebo for MDD. Data Extraction: Data were extracted independently by two of the authors. A random effects model was used to calculate the standardized mean difference (SMD) between esketamine and placebo (intranasal saline) in the Montgomery-Asberg Depression Rating Scale (MADRS) score change from baseline to endpoint, serving as the primary outcome of the study. Results: Five trials with 774 patients were pooled. Adjunctive esketamine was significantly more effective than placebo for MADRS score change, response, and remission (N = 774, SMD = 0.36, 95% CI = 0.24-0.49, P<.0001; response: risk ratio [RR] = 1.40, 95% CI = 1.22-1.61, P<.0001; remission: RR = 1.45, 95% CI = 1.20-1.75, P<.0001). Results remained statistically significant regardless of differences in the study sample, fixed vs new/optimized baseline antidepressants. Conclusions: Adjunctive intranasal esketamine for patients with MDD who are either treatment-resistant or acutely suicidal appears to be an effective treatment strategy.
AB - Objective: Esketamine, the S-enantiomer of ketamine, was recently approved as a rapid-acting intranasal therapy for depression and is currently under development for suicidality. The authors sought to determine the efficacy of adjunctive intranasal esketamine in major depressive disorder (MDD). Data Sources: A systematic search of PubMed/MEDLINE was conducted up to January 2019, in addition to abstracts of major psychiatric meetings held since 2010. Searches were conducted by cross-referencing the term intranasal with the term esketamine. Where necessary, authors and/or study sponsors were contacted in order to obtain a copy of the presentation as well as any pertinent study details. Study Selection: 241 study abstracts were initially identified and reviewed. Selected studies were randomized, double-blind clinical trials comparing adjunctive intranasal esketamine to adjunctive placebo for MDD. Data Extraction: Data were extracted independently by two of the authors. A random effects model was used to calculate the standardized mean difference (SMD) between esketamine and placebo (intranasal saline) in the Montgomery-Asberg Depression Rating Scale (MADRS) score change from baseline to endpoint, serving as the primary outcome of the study. Results: Five trials with 774 patients were pooled. Adjunctive esketamine was significantly more effective than placebo for MADRS score change, response, and remission (N = 774, SMD = 0.36, 95% CI = 0.24-0.49, P<.0001; response: risk ratio [RR] = 1.40, 95% CI = 1.22-1.61, P<.0001; remission: RR = 1.45, 95% CI = 1.20-1.75, P<.0001). Results remained statistically significant regardless of differences in the study sample, fixed vs new/optimized baseline antidepressants. Conclusions: Adjunctive intranasal esketamine for patients with MDD who are either treatment-resistant or acutely suicidal appears to be an effective treatment strategy.
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U2 - 10.4088/JCP.19r12889
DO - 10.4088/JCP.19r12889
M3 - Article
C2 - 32459407
AN - SCOPUS:85085539398
SN - 0160-6689
VL - 81
JO - Journal of Clinical Psychiatry
JF - Journal of Clinical Psychiatry
IS - 4
M1 - 19r12889
ER -