Efficacy of gatifloxacin in experimental Escherichia coli meningitis

Irja Lutsar, Ian R. Friedland, Hasan S. Jafri, Loretta Wubbel, Winston Ng, Faryal Ghaffar, George H. McCracken

Research output: Contribution to journalArticle

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Abstract

The effectiveness of gatifloxacin therapy (15 mg/kg every 5 h [q5h]) was compared with that of meropenem (75 mg/kg q5h) and cefotaxime (75 mg/kg q5h) therapy in experimental meningitis caused by a β-lactamase-producing strain of Escherichia coli. Gatifloxacin therapy was more rapidly bactericidal than cefotaxime but similar to meropenem therapy (bacterial killing rates at 5 h, 0.83 ± 0.26, 0.46 ± 0.3, and 0.73 ± 0.17 CFU/ml/h, respectively; P = 0.03 for gatifloxacin versus cefotaxime). At 10 h, seven of eight animals treated with gatifloxacin had <10 CFU/ml in their cerebrospinal fluid, compared with one of seven treated with cefotaxime therapy (P = 0.01). Gatifloxacin was at least as effective as currently available antibiotics in this model of E. coli meningitis.

Original languageEnglish (US)
Pages (from-to)1805-1807
Number of pages3
JournalAntimicrobial Agents and Chemotherapy
Volume43
Issue number7
StatePublished - Jul 1999

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Escherichia coli Meningitis
Cefotaxime
meropenem
Investigational Therapies
Therapeutics
Meningitis
Cerebrospinal Fluid
gatifloxacin
Escherichia coli
Anti-Bacterial Agents

ASJC Scopus subject areas

  • Pharmacology (medical)

Cite this

Lutsar, I., Friedland, I. R., Jafri, H. S., Wubbel, L., Ng, W., Ghaffar, F., & McCracken, G. H. (1999). Efficacy of gatifloxacin in experimental Escherichia coli meningitis. Antimicrobial Agents and Chemotherapy, 43(7), 1805-1807.

Efficacy of gatifloxacin in experimental Escherichia coli meningitis. / Lutsar, Irja; Friedland, Ian R.; Jafri, Hasan S.; Wubbel, Loretta; Ng, Winston; Ghaffar, Faryal; McCracken, George H.

In: Antimicrobial Agents and Chemotherapy, Vol. 43, No. 7, 07.1999, p. 1805-1807.

Research output: Contribution to journalArticle

Lutsar, I, Friedland, IR, Jafri, HS, Wubbel, L, Ng, W, Ghaffar, F & McCracken, GH 1999, 'Efficacy of gatifloxacin in experimental Escherichia coli meningitis', Antimicrobial Agents and Chemotherapy, vol. 43, no. 7, pp. 1805-1807.
Lutsar I, Friedland IR, Jafri HS, Wubbel L, Ng W, Ghaffar F et al. Efficacy of gatifloxacin in experimental Escherichia coli meningitis. Antimicrobial Agents and Chemotherapy. 1999 Jul;43(7):1805-1807.
Lutsar, Irja ; Friedland, Ian R. ; Jafri, Hasan S. ; Wubbel, Loretta ; Ng, Winston ; Ghaffar, Faryal ; McCracken, George H. / Efficacy of gatifloxacin in experimental Escherichia coli meningitis. In: Antimicrobial Agents and Chemotherapy. 1999 ; Vol. 43, No. 7. pp. 1805-1807.
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