Efficacy of humanized cefiderocol exposures over 72 hours against a diverse group of Gram-negative isolates in the neutropenic murine thigh infection model

Sean M. Stainton, Marguerite L. Monogue, Masakatsu Tsuji, Yoshinori Yamano, Roger Echols, David P. Nicolau

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Herein, we evaluated sustainability of humanized exposures of cefiderocol in vivo over 72 h against pathogens with cefiderocol MICs of 0.5 to 16 g/ml in the neutropenic murine thigh model. In Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacteriaceae displaying MICs of 0.5 to 8 g/ml (n 11), sustained kill was observed at 72 h among 9 isolates. Postexposure MICs revealed a single 2-dilution increase in one animal compared with controls (1/54 samples, 1.8%) at 72 h. Adaptive resistance during therapy was not observed.

Original languageEnglish (US)
Article numbere01040-18
JournalAntimicrobial Agents and Chemotherapy
Volume63
Issue number2
DOIs
StatePublished - Feb 2019
Externally publishedYes

Fingerprint

Acinetobacter baumannii
Enterobacteriaceae
Thigh
Pseudomonas aeruginosa
Infection
Therapeutics

Keywords

  • Gram-negative bacteria
  • Pharmacodynamics
  • Pharmacokinetics

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

Cite this

Efficacy of humanized cefiderocol exposures over 72 hours against a diverse group of Gram-negative isolates in the neutropenic murine thigh infection model. / Stainton, Sean M.; Monogue, Marguerite L.; Tsuji, Masakatsu; Yamano, Yoshinori; Echols, Roger; Nicolau, David P.

In: Antimicrobial Agents and Chemotherapy, Vol. 63, No. 2, e01040-18, 02.2019.

Research output: Contribution to journalArticle

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