@article{75eaeb7c53bf45ac9b4a9c24de5e625b,
title = "Efficacy of humanized cefiderocol exposures over 72 hours against a diverse group of Gram-negative isolates in the neutropenic murine thigh infection model",
abstract = "Herein, we evaluated sustainability of humanized exposures of cefiderocol in vivo over 72 h against pathogens with cefiderocol MICs of 0.5 to 16 g/ml in the neutropenic murine thigh model. In Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacteriaceae displaying MICs of 0.5 to 8 g/ml (n 11), sustained kill was observed at 72 h among 9 isolates. Postexposure MICs revealed a single 2-dilution increase in one animal compared with controls (1/54 samples, 1.8%) at 72 h. Adaptive resistance during therapy was not observed.",
keywords = "Gram-negative bacteria, Pharmacodynamics, Pharmacokinetics",
author = "Stainton, {Sean M.} and Monogue, {Marguerite L.} and Masakatsu Tsuji and Yoshinori Yamano and Roger Echols and Nicolau, {David P.}",
note = "Funding Information: We thank Safa Abuhussain, Kamilia Abdelraouf, Elizabeth Cyr, Sara Giovagnoli, Kimelyn Greenwood, Mordechai Grupper, Alissa Padgett, Jennifer Tabor-Rennie, Debora Santini, and Christina Sutherland of the Center for Anti-Infective Research and Development, Hartford, CT, for assistance with the conduct of the study. Additionally, we thank International Health Management Associates (IHMA), Mark Estabrook, and Mark Wise for assistance with the analysis of genotypic data. Funding for this study was provided by Shionogi & Co. Ltd. Osaka, Japan. Publisher Copyright: {\textcopyright} 2019 Stainton et al.",
year = "2019",
month = feb,
doi = "10.1128/AAC.01040-18",
language = "English (US)",
volume = "63",
journal = "Antimicrobial agents and chemotherapy",
issn = "0066-4804",
publisher = "American Society for Microbiology",
number = "2",
}