Efficacy of imagent BP at 1.5Ml/Kg in a rabbit liver tumor model

Kristine G. Baker, Holly B. Saunders, Robert F. Mattrey

Research output: Contribution to journalArticle

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Abstract

We have shown using a Vx2 rabbit model that 3 and 5ml/kg of perflubron emulsion were highly effective in imaging liver tumors. The results from preliminary clinical trials suggested that should the infusion rate be increased, a 1.5ml/kg may be efficacious. This study determined whether 1.5ml/kg given as a bolus IV would be efficacious to image liver tumors using a Vx2 rabbit model. Vx2 tumors were implanted in 5 NZW rabbits, CT of the liver was performed during held expiration at 80kV and 800mAS, before and shortly after 1.5ml/kg Imagent BP (ImBP), again at 30 minutes and 3 days. Regions of interest (ROIs) were drawn over the CT image of the spleen, liver, inferior vena cava, and tumor, CT# obtained and average enhancement of each tissue calculated at each time point. 4 animals had tumors 5cm or greater Precontrast, tumors were faintly seen on CT. Blood was brighter than liver shortly after infusion and isointense with liver at 30 minutes. Tumors did not enhance following contrast. Except for the liver and spleen, all tissues returned to baseline on the 3rd day. Therefore a clinical trial to determine the efficacy of 1.5ml/kg ImBP to image the liver is warranted.

Original languageEnglish (US)
Pages (from-to)1491-1499
Number of pages9
JournalArtificial Cells, Blood Substitutes, and Biotechnology
Volume22
Issue number4
DOIs
StatePublished - Jan 1994

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ASJC Scopus subject areas

  • Biotechnology
  • Biomedical Engineering

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