Efficacy of Porcine Secretin in Children with Autism and Pervasive Developmental Disorder

Janet K. Kern; Van S. Miller; Patricia A. Evans; Madhukar H. Trivedi

doi:10.1023/A:1015441428154

Efficacy of Porcine Secretin in Children with Autism and Pervasive Developmental Disorder

Janet K. Kern, Van S. Miller, Patricia A. Evans, Madhukar H. Trivedi

Research output: Contribution to journal › Article › peer-review

51 Scopus citations

Abstract

Secretin, a gastrointestinal (GI) hormone, was reported in a preliminary study to improve language and behavior in children with autism/pervasive developmental disorder (PDD) and chronic diarrhea. To determine the efficacy of secretin, we completed a double-blind, placebo-controlled, crossover (3 weeks) study in children with autism/PDD and various GI conditions using a single dose of intravenous porcine secretin. Children with chronic, active diarrhea showed a reduction in aberrant behaviors when treated with the secretin but not when treated with the placebo. Children with no GI problems are unaffected by either secretin or placebo. The improvement seen with secretin in children with autism/PDD and chronic diarrhea suggests that there may be a subtype of children with autism/PDD who respond to secretin.

Original language	English (US)
Pages (from-to)	153-160
Number of pages	8
Journal	Journal of Autism and Developmental Disorders
Volume	32
Issue number	3
DOIs	https://doi.org/10.1023/A:1015441428154
State	Published - Jun 2002

Keywords

Autism
Efficacy
Gastrointestinal
PDD
Secretin

ASJC Scopus subject areas

Developmental and Educational Psychology

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10.1023/A:1015441428154

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abstract = "Secretin, a gastrointestinal (GI) hormone, was reported in a preliminary study to improve language and behavior in children with autism/pervasive developmental disorder (PDD) and chronic diarrhea. To determine the efficacy of secretin, we completed a double-blind, placebo-controlled, crossover (3 weeks) study in children with autism/PDD and various GI conditions using a single dose of intravenous porcine secretin. Children with chronic, active diarrhea showed a reduction in aberrant behaviors when treated with the secretin but not when treated with the placebo. Children with no GI problems are unaffected by either secretin or placebo. The improvement seen with secretin in children with autism/PDD and chronic diarrhea suggests that there may be a subtype of children with autism/PDD who respond to secretin.",

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Efficacy of Porcine Secretin in Children with Autism and Pervasive Developmental Disorder

Abstract

Keywords

ASJC Scopus subject areas

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