Efficacy of Porcine Secretin in Children with Autism and Pervasive Developmental Disorder

Janet K. Kern, Van S. Miller, Patricia A. Evans, Madhukar H. Trivedi

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

Secretin, a gastrointestinal (GI) hormone, was reported in a preliminary study to improve language and behavior in children with autism/pervasive developmental disorder (PDD) and chronic diarrhea. To determine the efficacy of secretin, we completed a double-blind, placebo-controlled, crossover (3 weeks) study in children with autism/PDD and various GI conditions using a single dose of intravenous porcine secretin. Children with chronic, active diarrhea showed a reduction in aberrant behaviors when treated with the secretin but not when treated with the placebo. Children with no GI problems are unaffected by either secretin or placebo. The improvement seen with secretin in children with autism/PDD and chronic diarrhea suggests that there may be a subtype of children with autism/PDD who respond to secretin.

Original languageEnglish (US)
Pages (from-to)153-160
Number of pages8
JournalJournal of Autism and Developmental Disorders
Volume32
Issue number3
DOIs
StatePublished - Jun 2002

Fingerprint

Secretin
Autistic Disorder
Swine
Diarrhea
Placebos
Gastrointestinal Hormones
Child Behavior
Language

Keywords

  • Autism
  • Efficacy
  • Gastrointestinal
  • PDD
  • Secretin

ASJC Scopus subject areas

  • Psychology(all)
  • Developmental and Educational Psychology

Cite this

Efficacy of Porcine Secretin in Children with Autism and Pervasive Developmental Disorder. / Kern, Janet K.; Miller, Van S.; Evans, Patricia A.; Trivedi, Madhukar H.

In: Journal of Autism and Developmental Disorders, Vol. 32, No. 3, 06.2002, p. 153-160.

Research output: Contribution to journalArticle

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