Efficacy of Repeat AbobotulinumtoxinA (Dysport®) Injections in Improving Gait in Children with Spastic Cerebral Palsy

Nigar Dursun, Marcin Bonikowski, Edward Dabrowski, Dennis Matthews, Mark Gormley, Ann Tilton, Jorge Carranza, Anne Sophie Grandoulier, Philippe Picaut, Mauricio R. Delgado

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Purpose: This secondary analysis of a randomized, double-blind study plus open-label extension (NCT01249417/NCT01251380) evaluated the efficacy of abobotulinumtoxinA versus placebo in improving gait pattern in children with dynamic equinus due to cerebral palsy (CP) as assessed by the observational gait scale (OGS). Methods: Ambulatory children with CP (N = 241, aged 2–17) and dynamic equinus were randomized to treatment with abobotulinumtoxinA (10 or 15U/kg/leg) or placebo injected into the gastrocsoleus. All children received abobotulinumtoxinA in the open-label phase. Results: In the double-blind phase, abobotulinumtoxinA significantly improved OGS total scores versus placebo at Week 4 (treatment effect vs. placebo: 10U/kg/leg: 1.5 [0.7, 2.3], p = .0003; 15U/kg/leg: 1.1 [0.3, 1.9], p = .01). In the open-label phase, treatment with abobotulinumtoxinA continued to improve the OGS score at the same magnitude as seen in the double-blind study. Conclusion: Repeat treatment with abobotulinumtoxinA improved gait in children with dynamic equinus.

Original languageEnglish (US)
JournalDevelopmental Neurorehabilitation
DOIs
StateAccepted/In press - 2019

Keywords

  • Abobotulinumtoxina
  • botulinum toxin
  • cerebral palsy
  • dynamic equinus
  • gait

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Rehabilitation
  • Developmental Neuroscience

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    Dursun, N., Bonikowski, M., Dabrowski, E., Matthews, D., Gormley, M., Tilton, A., Carranza, J., Grandoulier, A. S., Picaut, P., & Delgado, M. R. (Accepted/In press). Efficacy of Repeat AbobotulinumtoxinA (Dysport®) Injections in Improving Gait in Children with Spastic Cerebral Palsy. Developmental Neurorehabilitation. https://doi.org/10.1080/17518423.2019.1687602