Abstract
Purpose: This secondary analysis of a randomized, double-blind study plus open-label extension (NCT01249417/NCT01251380) evaluated the efficacy of abobotulinumtoxinA versus placebo in improving gait pattern in children with dynamic equinus due to cerebral palsy (CP) as assessed by the observational gait scale (OGS). Methods: Ambulatory children with CP (N = 241, aged 2–17) and dynamic equinus were randomized to treatment with abobotulinumtoxinA (10 or 15U/kg/leg) or placebo injected into the gastrocsoleus. All children received abobotulinumtoxinA in the open-label phase. Results: In the double-blind phase, abobotulinumtoxinA significantly improved OGS total scores versus placebo at Week 4 (treatment effect vs. placebo: 10U/kg/leg: 1.5 [0.7, 2.3], p = .0003; 15U/kg/leg: 1.1 [0.3, 1.9], p = .01). In the open-label phase, treatment with abobotulinumtoxinA continued to improve the OGS score at the same magnitude as seen in the double-blind study. Conclusion: Repeat treatment with abobotulinumtoxinA improved gait in children with dynamic equinus.
Original language | English (US) |
---|---|
Pages (from-to) | 368-374 |
Number of pages | 7 |
Journal | Developmental Neurorehabilitation |
Volume | 23 |
Issue number | 6 |
DOIs | |
State | Published - Aug 17 2020 |
Keywords
- Abobotulinumtoxina
- botulinum toxin
- cerebral palsy
- dynamic equinus
- gait
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
- Rehabilitation
- Developmental Neuroscience