Efficient synthesis of 2-mono- and 2,5-disubstituted furans via the CuI-catalyzed cycloisomerization of alkynyl ketonest

Alexander V. Kel'in, Vladimir Gevorgyan

Research output: Contribution to journalArticle

199 Scopus citations

Abstract

A mild, general, and efficient method for the synthesis of 2-monosubstituted and 2,5-disubstituted furans via the CuI-catalyzed cycloisomerization of alkynyl ketones was developed. It was demonstrated that furans containing both acid- and base-labile groups could be easily synthesized using this methodology. A plausible mechanism for this transformation is proposed.

Original languageEnglish (US)
Pages (from-to)95-98
Number of pages4
JournalJournal of Organic Chemistry
Volume67
Issue number1
DOIs
StatePublished - Jan 11 2002
Externally publishedYes

ASJC Scopus subject areas

  • Organic Chemistry

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