Efficient total synthesis of 5-oxo-6(E),8(Z),11(Z),14(Z)-eicosatetraenoic acid (5-oxo-ETE), a potent proinflammatory autacoid

Suchismita Mohapatra, Jorge H. Capdevila, Robert C. Murphy, John M. Hevko, J R Falck

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

The title eicosanoid was prepared in good overall yield via a convergent aldol strategy that obviates the need for HPLC separation of olefinic isomers.

Original languageEnglish (US)
Pages (from-to)4109-4110
Number of pages2
JournalTetrahedron Letters
Volume42
Issue number25
DOIs
StatePublished - Jun 18 2001

Keywords

  • Aldol reactions
  • Biologically active compounds
  • Eicosanoids
  • Hydrogenation
  • Metabolites

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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