Efficient total synthesis of 5-oxo-6(E),8(Z),11(Z),14(Z)-eicosatetraenoic acid (5-oxo-ETE), a potent proinflammatory autacoid

Suchismita Mohapatra; Jorge H. Capdevila; Robert C. Murphy; John M. Hevko; J R Falck

doi:10.1016/S0040-4039(01)00668-2

Efficient total synthesis of 5-oxo-6(E),8(Z),11(Z),14(Z)-eicosatetraenoic acid (5-oxo-ETE), a potent proinflammatory autacoid

Suchismita Mohapatra, Jorge H. Capdevila, Robert C. Murphy, John M. Hevko, J R Falck

Biochemistry

Research output: Contribution to journal › Article

6 Scopus citations

Abstract

The title eicosanoid was prepared in good overall yield via a convergent aldol strategy that obviates the need for HPLC separation of olefinic isomers.

Original language	English (US)
Pages (from-to)	4109-4110
Number of pages	2
Journal	Tetrahedron Letters
Volume	42
Issue number	25
DOIs	https://doi.org/10.1016/S0040-4039(01)00668-2
State	Published - Jun 18 2001

Keywords

Aldol reactions
Biologically active compounds
Eicosanoids
Hydrogenation
Metabolites

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/S0040-4039(01)00668-2

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Mohapatra, S., Capdevila, J. H., Murphy, R. C., Hevko, J. M., & Falck, J. R. (2001). Efficient total synthesis of 5-oxo-6(E),8(Z),11(Z),14(Z)-eicosatetraenoic acid (5-oxo-ETE), a potent proinflammatory autacoid. Tetrahedron Letters, 42(25), 4109-4110. https://doi.org/10.1016/S0040-4039(01)00668-2

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abstract = "The title eicosanoid was prepared in good overall yield via a convergent aldol strategy that obviates the need for HPLC separation of olefinic isomers.",

keywords = "Aldol reactions, Biologically active compounds, Eicosanoids, Hydrogenation, Metabolites",

author = "Suchismita Mohapatra and Capdevila, {Jorge H.} and Murphy, {Robert C.} and Hevko, {John M.} and Falck, {J R}",

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AU - Capdevila, Jorge H.

AU - Murphy, Robert C.

AU - Hevko, John M.

AU - Falck, J R

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KW - Hydrogenation

KW - Metabolites

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