Efficient total synthesis of 5-oxo-6(E),8(Z),11(Z),14(Z)-eicosatetraenoic acid (5-oxo-ETE), a potent proinflammatory autacoid

Suchismita Mohapatra; Jorge H. Capdevila; Robert C. Murphy; John M. Hevko; J R Falck

doi:10.1016/S0040-4039(01)00668-2

Efficient total synthesis of 5-oxo-6(E),8(Z),11(Z),14(Z)-eicosatetraenoic acid (5-oxo-ETE), a potent proinflammatory autacoid

Suchismita Mohapatra, Jorge H. Capdevila, Robert C. Murphy, John M. Hevko, J R Falck

Biochemistry

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

The title eicosanoid was prepared in good overall yield via a convergent aldol strategy that obviates the need for HPLC separation of olefinic isomers.

Original language	English (US)
Pages (from-to)	4109-4110
Number of pages	2
Journal	Tetrahedron Letters
Volume	42
Issue number	25
DOIs	https://doi.org/10.1016/S0040-4039(01)00668-2
State	Published - Jun 18 2001

Keywords

Aldol reactions
Biologically active compounds
Eicosanoids
Hydrogenation
Metabolites

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

Access to Document

10.1016/S0040-4039(01)00668-2

Fingerprint Dive into the research topics of 'Efficient total synthesis of 5-oxo-6(E),8(Z),11(Z),14(Z)-eicosatetraenoic acid (5-oxo-ETE), a potent proinflammatory autacoid'. Together they form a unique fingerprint.

Cite this

@article{2cc186e2a78c4231a5496e406723a8dc,

title = "Efficient total synthesis of 5-oxo-6(E),8(Z),11(Z),14(Z)-eicosatetraenoic acid (5-oxo-ETE), a potent proinflammatory autacoid",

abstract = "The title eicosanoid was prepared in good overall yield via a convergent aldol strategy that obviates the need for HPLC separation of olefinic isomers.",

keywords = "Aldol reactions, Biologically active compounds, Eicosanoids, Hydrogenation, Metabolites",

author = "Suchismita Mohapatra and Capdevila, {Jorge H.} and Murphy, {Robert C.} and Hevko, {John M.} and Falck, {J R}",

year = "2001",

month = jun,

day = "18",

doi = "10.1016/S0040-4039(01)00668-2",

language = "English (US)",

volume = "42",

pages = "4109--4110",

journal = "Tetrahedron Letters",

issn = "0040-4039",

publisher = "Elsevier Limited",

number = "25",

}

TY - JOUR

T1 - Efficient total synthesis of 5-oxo-6(E),8(Z),11(Z),14(Z)-eicosatetraenoic acid (5-oxo-ETE), a potent proinflammatory autacoid

AU - Mohapatra, Suchismita

AU - Capdevila, Jorge H.

AU - Murphy, Robert C.

AU - Hevko, John M.

AU - Falck, J R

PY - 2001/6/18

Y1 - 2001/6/18

N2 - The title eicosanoid was prepared in good overall yield via a convergent aldol strategy that obviates the need for HPLC separation of olefinic isomers.

AB - The title eicosanoid was prepared in good overall yield via a convergent aldol strategy that obviates the need for HPLC separation of olefinic isomers.

KW - Aldol reactions

KW - Biologically active compounds

KW - Eicosanoids

KW - Hydrogenation

KW - Metabolites

UR - http://www.scopus.com/inward/record.url?scp=0035908258&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035908258&partnerID=8YFLogxK

U2 - 10.1016/S0040-4039(01)00668-2

DO - 10.1016/S0040-4039(01)00668-2

M3 - Article

AN - SCOPUS:0035908258

VL - 42

SP - 4109

EP - 4110

JO - Tetrahedron Letters

JF - Tetrahedron Letters

SN - 0040-4039

IS - 25

ER -