Eggs to die for: Cell death during Drosophila oogenesis

M. Buszczak, L. Cooley

Research output: Contribution to journalReview article

79 Scopus citations

Abstract

Extensive programmed cell death occurs in the female germline of many species ranging from C. elegans to humans. One purpose for germline apoptosis is to remove defective cells unable to develop into fertile eggs. In addition, recent work suggests that the death of specific germline cells may also play a vital role by providing essential nutrients to the surviving oocytes. In Drosophila, the genetic control of germline apoptosis and the proteins that carry out the death sentences are beginning to emerge from studies of female sterile mutations. These studies suggest that the morphological changes that occur during the late stages of Drosophila oogenesis may be initiated and driven by a modified form of programmed cell death.

Original languageEnglish (US)
Pages (from-to)1071-1074
Number of pages4
JournalCell Death and Differentiation
Volume7
Issue number11
DOIs
StatePublished - Jan 1 2000

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Keywords

  • Apoptosis
  • Drosophila
  • Germline
  • Nurse cell

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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