EglN2 positively regulates mitochondrial function in breast cancer

Jing Zhang, Xingnan Zheng, Qing Zhang

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Oxygen sensing is associated with mitochondrial function. EglN2, which contributes to breast tumorigenesis as a prolyl hydroxylase, has recently been identified as a transcription co-activator through interaction with NRF1 and PGC1α to regulate mitochondrial function under conditions of normoxia and hypoxia. FDXR is the important downstream target gene that mediates this regulation.

Original languageEnglish (US)
Article numbere1120845
JournalMolecular and Cellular Oncology
Volume3
Issue number2
DOIs
StatePublished - Mar 3 2016

Keywords

  • Breast cancer
  • EglN2
  • FDXR
  • hypoxia
  • mitochondria

ASJC Scopus subject areas

  • Molecular Medicine
  • Cancer Research

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