EglN2 positively regulates mitochondrial function in breast cancer

Jing Zhang; Xingnan Zheng; Qing Zhang

doi:10.1080/23723556.2015.1120845

EglN2 positively regulates mitochondrial function in breast cancer

Jing Zhang, Xingnan Zheng, Qing Zhang

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Oxygen sensing is associated with mitochondrial function. EglN2, which contributes to breast tumorigenesis as a prolyl hydroxylase, has recently been identified as a transcription co-activator through interaction with NRF1 and PGC1α to regulate mitochondrial function under conditions of normoxia and hypoxia. FDXR is the important downstream target gene that mediates this regulation.

Original language	English (US)
Article number	e1120845
Journal	Molecular and Cellular Oncology
Volume	3
Issue number	2
DOIs	https://doi.org/10.1080/23723556.2015.1120845
State	Published - Mar 3 2016
Externally published	Yes

Keywords

Breast cancer
EglN2
FDXR
hypoxia
mitochondria

ASJC Scopus subject areas

Molecular Medicine
Cancer Research

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10.1080/23723556.2015.1120845

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title = "EglN2 positively regulates mitochondrial function in breast cancer",

abstract = "Oxygen sensing is associated with mitochondrial function. EglN2, which contributes to breast tumorigenesis as a prolyl hydroxylase, has recently been identified as a transcription co-activator through interaction with NRF1 and PGC1α to regulate mitochondrial function under conditions of normoxia and hypoxia. FDXR is the important downstream target gene that mediates this regulation.",

keywords = "Breast cancer, EglN2, FDXR, hypoxia, mitochondria",

author = "Jing Zhang and Xingnan Zheng and Qing Zhang",

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AU - Zhang, Jing

AU - Zheng, Xingnan

AU - Zhang, Qing

PY - 2016/3/3

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N2 - Oxygen sensing is associated with mitochondrial function. EglN2, which contributes to breast tumorigenesis as a prolyl hydroxylase, has recently been identified as a transcription co-activator through interaction with NRF1 and PGC1α to regulate mitochondrial function under conditions of normoxia and hypoxia. FDXR is the important downstream target gene that mediates this regulation.

AB - Oxygen sensing is associated with mitochondrial function. EglN2, which contributes to breast tumorigenesis as a prolyl hydroxylase, has recently been identified as a transcription co-activator through interaction with NRF1 and PGC1α to regulate mitochondrial function under conditions of normoxia and hypoxia. FDXR is the important downstream target gene that mediates this regulation.

KW - Breast cancer

KW - EglN2

KW - FDXR

KW - hypoxia

KW - mitochondria

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ER -

EglN2 positively regulates mitochondrial function in breast cancer

Abstract

Keywords

ASJC Scopus subject areas

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