Eicosanoid biosynthesis: Differential inhibition of cytochrome P450 epoxygenase and ω-hydroxylase

J R Falck, Yuri Y. Belosludtsev, K. Kishta Reddy, Komandla Malla Reddy, M. Fiona Shortt, Kamlesh Chauhan, Jorge H. Capdevilaand, Shozou Wei

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Biphenyl 4 and vinyldibromide 8 were prepared on a multigram scale and shown to be comparatively specific arachidonic acid epoxygenase and ω-hydroxylase inhibitors, respectively, in rat kidney microsomal fractions.

Original languageEnglish (US)
Pages (from-to)3053-3056
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume7
Issue number23
DOIs
StatePublished - Dec 2 1997

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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    Falck, J. R., Belosludtsev, Y. Y., Reddy, K. K., Reddy, K. M., Shortt, M. F., Chauhan, K., Capdevilaand, J. H., & Wei, S. (1997). Eicosanoid biosynthesis: Differential inhibition of cytochrome P450 epoxygenase and ω-hydroxylase. Bioorganic and Medicinal Chemistry Letters, 7(23), 3053-3056. https://doi.org/10.1016/S0960-894X(97)10144-5