Eicosanoid biosynthesis

Differential inhibition of cytochrome P450 epoxygenase and ω-hydroxylase

J R Falck, Yuri Y. Belosludtsev, K. Kishta Reddy, Komandla Malla Reddy, M. Fiona Shortt, Kamlesh Chauhan, Jorge H. Capdevilaand, Shozou Wei

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Biphenyl 4 and vinyldibromide 8 were prepared on a multigram scale and shown to be comparatively specific arachidonic acid epoxygenase and ω-hydroxylase inhibitors, respectively, in rat kidney microsomal fractions.

Original languageEnglish (US)
Pages (from-to)3053-3056
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume7
Issue number23
StatePublished - Dec 2 1997

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Eicosanoids
Biosynthesis
Mixed Function Oxygenases
Cytochrome P-450 Enzyme System
Rats
Kidney
arachidonate epoxygenase
diphenyl

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

Cite this

Falck, J. R., Belosludtsev, Y. Y., Reddy, K. K., Reddy, K. M., Shortt, M. F., Chauhan, K., ... Wei, S. (1997). Eicosanoid biosynthesis: Differential inhibition of cytochrome P450 epoxygenase and ω-hydroxylase. Bioorganic and Medicinal Chemistry Letters, 7(23), 3053-3056.

Eicosanoid biosynthesis : Differential inhibition of cytochrome P450 epoxygenase and ω-hydroxylase. / Falck, J R; Belosludtsev, Yuri Y.; Reddy, K. Kishta; Reddy, Komandla Malla; Shortt, M. Fiona; Chauhan, Kamlesh; Capdevilaand, Jorge H.; Wei, Shozou.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 7, No. 23, 02.12.1997, p. 3053-3056.

Research output: Contribution to journalArticle

Falck, JR, Belosludtsev, YY, Reddy, KK, Reddy, KM, Shortt, MF, Chauhan, K, Capdevilaand, JH & Wei, S 1997, 'Eicosanoid biosynthesis: Differential inhibition of cytochrome P450 epoxygenase and ω-hydroxylase', Bioorganic and Medicinal Chemistry Letters, vol. 7, no. 23, pp. 3053-3056.
Falck, J R ; Belosludtsev, Yuri Y. ; Reddy, K. Kishta ; Reddy, Komandla Malla ; Shortt, M. Fiona ; Chauhan, Kamlesh ; Capdevilaand, Jorge H. ; Wei, Shozou. / Eicosanoid biosynthesis : Differential inhibition of cytochrome P450 epoxygenase and ω-hydroxylase. In: Bioorganic and Medicinal Chemistry Letters. 1997 ; Vol. 7, No. 23. pp. 3053-3056.
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