Elastrographic assessment of micromotion-induced strain in tissue adjacent to intracortical implants in rat

Allison M. Stiller; Lokesh Basavarajappa; Katherine Brown; Walter Voit; Joseph J. Pancrazio; Kenneth Hoyt

doi:10.1109/ULTSYM.2019.8925593

Elastrographic assessment of micromotion-induced strain in tissue adjacent to intracortical implants in rat

Allison M. Stiller, Lokesh Basavarajappa, Katherine Brown, Walter Voit, Joseph J. Pancrazio, Kenneth Hoyt

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

2 Scopus citations

Abstract

Intracortical electrodes are important components of neural interfaces, but are limited in clinical applications due to high rates of device failure. This is in part due to a chronic neuroinflammatory response, which may be a result of mechanical mismatch between stiff implanted devices and the surrounding tissue. In this study, we used ultrasound (US)-based elastography to measure strain maps in vivo around intracortical devices. Experiments were performed by implanting shape memory polymer (soft) and silicon (stiff) devices in rat cortex. The results indicate higher strains in regions-of-interest containing stiff devices, indicating the possible effects of mechanical mismatch on micromotion-induced tissue strain.

Original language	English (US)
Title of host publication	2019 IEEE International Ultrasonics Symposium, IUS 2019
Publisher	IEEE Computer Society
Pages	435-438
Number of pages	4
ISBN (Electronic)	9781728145969
DOIs	https://doi.org/10.1109/ULTSYM.2019.8925593
State	Published - Oct 2019
Event	2019 IEEE International Ultrasonics Symposium, IUS 2019 - Glasgow, United Kingdom Duration: Oct 6 2019 → Oct 9 2019

Publication series

Name	IEEE International Ultrasonics Symposium, IUS
Volume	2019-October
ISSN (Print)	1948-5719
ISSN (Electronic)	1948-5727

Conference

Conference	2019 IEEE International Ultrasonics Symposium, IUS 2019
Country/Territory	United Kingdom
City	Glasgow
Period	10/6/19 → 10/9/19

Keywords

Share memory polymer (SMP)
elastography
neuroinflammation
strain
ultrasound

ASJC Scopus subject areas

Acoustics and Ultrasonics

Access to Document

10.1109/ULTSYM.2019.8925593

Cite this

Stiller, A. M., Basavarajappa, L., Brown, K., Voit, W., Pancrazio, J. J., & Hoyt, K. (2019). Elastrographic assessment of micromotion-induced strain in tissue adjacent to intracortical implants in rat. In 2019 IEEE International Ultrasonics Symposium, IUS 2019 (pp. 435-438). Article 8925593 (IEEE International Ultrasonics Symposium, IUS; Vol. 2019-October). IEEE Computer Society. https://doi.org/10.1109/ULTSYM.2019.8925593

Elastrographic assessment of micromotion-induced strain in tissue adjacent to intracortical implants in rat. / Stiller, Allison M.; Basavarajappa, Lokesh; Brown, Katherine et al.
2019 IEEE International Ultrasonics Symposium, IUS 2019. IEEE Computer Society, 2019. p. 435-438 8925593 (IEEE International Ultrasonics Symposium, IUS; Vol. 2019-October).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Stiller, AM, Basavarajappa, L, Brown, K, Voit, W, Pancrazio, JJ & Hoyt, K 2019, Elastrographic assessment of micromotion-induced strain in tissue adjacent to intracortical implants in rat. in 2019 IEEE International Ultrasonics Symposium, IUS 2019., 8925593, IEEE International Ultrasonics Symposium, IUS, vol. 2019-October, IEEE Computer Society, pp. 435-438, 2019 IEEE International Ultrasonics Symposium, IUS 2019, Glasgow, United Kingdom, 10/6/19. https://doi.org/10.1109/ULTSYM.2019.8925593

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abstract = "Intracortical electrodes are important components of neural interfaces, but are limited in clinical applications due to high rates of device failure. This is in part due to a chronic neuroinflammatory response, which may be a result of mechanical mismatch between stiff implanted devices and the surrounding tissue. In this study, we used ultrasound (US)-based elastography to measure strain maps in vivo around intracortical devices. Experiments were performed by implanting shape memory polymer (soft) and silicon (stiff) devices in rat cortex. The results indicate higher strains in regions-of-interest containing stiff devices, indicating the possible effects of mechanical mismatch on micromotion-induced tissue strain.",

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Elastrographic assessment of micromotion-induced strain in tissue adjacent to intracortical implants in rat

Abstract

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Keywords

ASJC Scopus subject areas

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