Elastrographic assessment of micromotion-induced strain in tissue adjacent to intracortical implants in rat

Allison M. Stiller, Lokesh Basavarajappa, Katherine Brown, Walter Voit, Joseph J. Pancrazio, Kenneth Hoyt

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Intracortical electrodes are important components of neural interfaces, but are limited in clinical applications due to high rates of device failure. This is in part due to a chronic neuroinflammatory response, which may be a result of mechanical mismatch between stiff implanted devices and the surrounding tissue. In this study, we used ultrasound (US)-based elastography to measure strain maps in vivo around intracortical devices. Experiments were performed by implanting shape memory polymer (soft) and silicon (stiff) devices in rat cortex. The results indicate higher strains in regions-of-interest containing stiff devices, indicating the possible effects of mechanical mismatch on micromotion-induced tissue strain.

Original languageEnglish (US)
Title of host publication2019 IEEE International Ultrasonics Symposium, IUS 2019
PublisherIEEE Computer Society
Pages435-438
Number of pages4
ISBN (Electronic)9781728145969
DOIs
StatePublished - Oct 2019
Externally publishedYes
Event2019 IEEE International Ultrasonics Symposium, IUS 2019 - Glasgow, United Kingdom
Duration: Oct 6 2019Oct 9 2019

Publication series

NameIEEE International Ultrasonics Symposium, IUS
Volume2019-October
ISSN (Print)1948-5719
ISSN (Electronic)1948-5727

Conference

Conference2019 IEEE International Ultrasonics Symposium, IUS 2019
CountryUnited Kingdom
CityGlasgow
Period10/6/1910/9/19

Keywords

  • elastography
  • neuroinflammation
  • Share memory polymer (SMP)
  • strain
  • ultrasound

ASJC Scopus subject areas

  • Acoustics and Ultrasonics

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  • Cite this

    Stiller, A. M., Basavarajappa, L., Brown, K., Voit, W., Pancrazio, J. J., & Hoyt, K. (2019). Elastrographic assessment of micromotion-induced strain in tissue adjacent to intracortical implants in rat. In 2019 IEEE International Ultrasonics Symposium, IUS 2019 (pp. 435-438). [8925593] (IEEE International Ultrasonics Symposium, IUS; Vol. 2019-October). IEEE Computer Society. https://doi.org/10.1109/ULTSYM.2019.8925593