Elderly diabetics with peripheral arterial disease and no coronary artery disease have a higher incidence of new coronary events than elderly nondiabetics with peripheral arterial disease and prior myocardial infarction treated with statins and with no lipid-lowering drug

Wilbert S. Aronow, Chul Ahn

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35 Citations (Scopus)

Abstract

Background. We report data showing the incidence of new coronary events in diabetics with prior myocardial infarction (MI), nondiabetics with prior MI, diabetes with no coronary artery disease (CAD), and nondiabetics with no CAD who were treated with and without statins. Methods. We investigated - in an observational prospective study of 274 diabetics and 386 nondiabetics with peripheral arterial disease, mean age 80 ± 9 years, and a serum low-density lipoprotein cholesterol level of > 125 mg/dl - the incidence of new coronary events in diabetics with prior MI, nondiabetics with prior MI, diabetics with no CAD, and nondiabetics with no CAD who were treated with and without statins. Follow-up was 39 ± 23 months. Results. In patients treated with statins, the incidence of new coronary events was 73% in diabetics with prior MI (group 1), 37% in nondiabetics with prior MI (group 2), 57% in diabetics with no CAD (group 3), and 27% in nondiabetics with no CAD (group 4). In patients treated with no lipid-lowering drug, the incidence of new coronary events was 91% in diabetics with prior MI (group 5), 72% in nondiabetics with prior MI (group 6), 86% in diabetics with no CAD (group 7), and 52% in nondiabetics with no CAD (group 8). Significant p values were p < .0001 for group 1 versus 2, group 7 versus 8, and group 2 versus 6; p=.0006 for group 3 versus 4; p=.0007 for group 3 versus 7; p=.001 for group 5 versus 6; p=.002 for group 4 versus 8; p=.003 for group I versus 5; p=.015 for group 2 versus 3; and p=.047 for group 6 versus 7. Conclusions. In patients treated with and without statins, diabetics with no CAD had a higher incidence of new coronary events than did nondiabetics with prior MI.

Original languageEnglish (US)
Pages (from-to)573-575
Number of pages3
JournalJournals of Gerontology - Series A Biological Sciences and Medical Sciences
Volume58
Issue number6
StatePublished - Jun 1 2003

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Hydroxymethylglutaryl-CoA Reductase Inhibitors
Peripheral Arterial Disease
Coronary Artery Disease
Myocardial Infarction
Lipids
Incidence
Pharmaceutical Preparations
LDL Cholesterol
Observational Studies
Prospective Studies

ASJC Scopus subject areas

  • Aging

Cite this

@article{4991d48679e04bed8d35bfa5662e2e4c,
title = "Elderly diabetics with peripheral arterial disease and no coronary artery disease have a higher incidence of new coronary events than elderly nondiabetics with peripheral arterial disease and prior myocardial infarction treated with statins and with no lipid-lowering drug",
abstract = "Background. We report data showing the incidence of new coronary events in diabetics with prior myocardial infarction (MI), nondiabetics with prior MI, diabetes with no coronary artery disease (CAD), and nondiabetics with no CAD who were treated with and without statins. Methods. We investigated - in an observational prospective study of 274 diabetics and 386 nondiabetics with peripheral arterial disease, mean age 80 ± 9 years, and a serum low-density lipoprotein cholesterol level of > 125 mg/dl - the incidence of new coronary events in diabetics with prior MI, nondiabetics with prior MI, diabetics with no CAD, and nondiabetics with no CAD who were treated with and without statins. Follow-up was 39 ± 23 months. Results. In patients treated with statins, the incidence of new coronary events was 73{\%} in diabetics with prior MI (group 1), 37{\%} in nondiabetics with prior MI (group 2), 57{\%} in diabetics with no CAD (group 3), and 27{\%} in nondiabetics with no CAD (group 4). In patients treated with no lipid-lowering drug, the incidence of new coronary events was 91{\%} in diabetics with prior MI (group 5), 72{\%} in nondiabetics with prior MI (group 6), 86{\%} in diabetics with no CAD (group 7), and 52{\%} in nondiabetics with no CAD (group 8). Significant p values were p < .0001 for group 1 versus 2, group 7 versus 8, and group 2 versus 6; p=.0006 for group 3 versus 4; p=.0007 for group 3 versus 7; p=.001 for group 5 versus 6; p=.002 for group 4 versus 8; p=.003 for group I versus 5; p=.015 for group 2 versus 3; and p=.047 for group 6 versus 7. Conclusions. In patients treated with and without statins, diabetics with no CAD had a higher incidence of new coronary events than did nondiabetics with prior MI.",
author = "Aronow, {Wilbert S.} and Chul Ahn",
year = "2003",
month = "6",
day = "1",
language = "English (US)",
volume = "58",
pages = "573--575",
journal = "Journals of Gerontology - Series A Biological Sciences and Medical Sciences",
issn = "1079-5006",
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TY - JOUR

T1 - Elderly diabetics with peripheral arterial disease and no coronary artery disease have a higher incidence of new coronary events than elderly nondiabetics with peripheral arterial disease and prior myocardial infarction treated with statins and with no lipid-lowering drug

AU - Aronow, Wilbert S.

AU - Ahn, Chul

PY - 2003/6/1

Y1 - 2003/6/1

N2 - Background. We report data showing the incidence of new coronary events in diabetics with prior myocardial infarction (MI), nondiabetics with prior MI, diabetes with no coronary artery disease (CAD), and nondiabetics with no CAD who were treated with and without statins. Methods. We investigated - in an observational prospective study of 274 diabetics and 386 nondiabetics with peripheral arterial disease, mean age 80 ± 9 years, and a serum low-density lipoprotein cholesterol level of > 125 mg/dl - the incidence of new coronary events in diabetics with prior MI, nondiabetics with prior MI, diabetics with no CAD, and nondiabetics with no CAD who were treated with and without statins. Follow-up was 39 ± 23 months. Results. In patients treated with statins, the incidence of new coronary events was 73% in diabetics with prior MI (group 1), 37% in nondiabetics with prior MI (group 2), 57% in diabetics with no CAD (group 3), and 27% in nondiabetics with no CAD (group 4). In patients treated with no lipid-lowering drug, the incidence of new coronary events was 91% in diabetics with prior MI (group 5), 72% in nondiabetics with prior MI (group 6), 86% in diabetics with no CAD (group 7), and 52% in nondiabetics with no CAD (group 8). Significant p values were p < .0001 for group 1 versus 2, group 7 versus 8, and group 2 versus 6; p=.0006 for group 3 versus 4; p=.0007 for group 3 versus 7; p=.001 for group 5 versus 6; p=.002 for group 4 versus 8; p=.003 for group I versus 5; p=.015 for group 2 versus 3; and p=.047 for group 6 versus 7. Conclusions. In patients treated with and without statins, diabetics with no CAD had a higher incidence of new coronary events than did nondiabetics with prior MI.

AB - Background. We report data showing the incidence of new coronary events in diabetics with prior myocardial infarction (MI), nondiabetics with prior MI, diabetes with no coronary artery disease (CAD), and nondiabetics with no CAD who were treated with and without statins. Methods. We investigated - in an observational prospective study of 274 diabetics and 386 nondiabetics with peripheral arterial disease, mean age 80 ± 9 years, and a serum low-density lipoprotein cholesterol level of > 125 mg/dl - the incidence of new coronary events in diabetics with prior MI, nondiabetics with prior MI, diabetics with no CAD, and nondiabetics with no CAD who were treated with and without statins. Follow-up was 39 ± 23 months. Results. In patients treated with statins, the incidence of new coronary events was 73% in diabetics with prior MI (group 1), 37% in nondiabetics with prior MI (group 2), 57% in diabetics with no CAD (group 3), and 27% in nondiabetics with no CAD (group 4). In patients treated with no lipid-lowering drug, the incidence of new coronary events was 91% in diabetics with prior MI (group 5), 72% in nondiabetics with prior MI (group 6), 86% in diabetics with no CAD (group 7), and 52% in nondiabetics with no CAD (group 8). Significant p values were p < .0001 for group 1 versus 2, group 7 versus 8, and group 2 versus 6; p=.0006 for group 3 versus 4; p=.0007 for group 3 versus 7; p=.001 for group 5 versus 6; p=.002 for group 4 versus 8; p=.003 for group I versus 5; p=.015 for group 2 versus 3; and p=.047 for group 6 versus 7. Conclusions. In patients treated with and without statins, diabetics with no CAD had a higher incidence of new coronary events than did nondiabetics with prior MI.

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M3 - Article

VL - 58

SP - 573

EP - 575

JO - Journals of Gerontology - Series A Biological Sciences and Medical Sciences

JF - Journals of Gerontology - Series A Biological Sciences and Medical Sciences

SN - 1079-5006

IS - 6

ER -