Elderly recipients of hepatitis c positive renal allografts can quickly develop liver disease

Tanya R. Flohr, Hugo Bonatti, Tjasa Hranjec, Doug S. Keith, Peter I. Lobo, Sean C. Kumer, Timothy M. Schmitt, Robert G. Sawyer, Timothy L. Pruett, John P. Roberts, Kenneth L. Brayman

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Our institution explored using allografts from donors with Hepatitis C virus (HCV) for elderly renal transplantation (RT). Thirteen HCV- elderly recipients were transplanted with HCV+ allografts (eD+/R-) between January 2003 and April 2009. Ninety HCV- elderly recipients of HCV- allografts (eD-/R-), eight HCV+ recipients of HCV+ allografts (D+/R+) and thirteen HCV+ recipients of HCV- allografts (D-/R+) were also transplanted. Median follow-up was 1.5 (range 0.8-5) years. Seven eD+/R- developed a positive HCV viral load and six had elevated liver transaminases with evidence of hepatitis on biopsy. Overall, eD+/R- survival was 46% while the eD-/R- survival was 85% (P = 0.003). Seven eD+/R- died during follow-up. Causes included multi-organ failure and sepsis (n = 4), cancer (n = 1), failure-to-thrive (n = 1) and surgical complications (n = 1). One eD+/R- died from causes directly related to HCV infection. In conclusion, multiple eD+/R- quickly developed HCV-related liver disease and infections were a frequent cause of morbidity and mortality.

Original languageEnglish (US)
Pages (from-to)629-638
Number of pages10
JournalJournal of Surgical Research
Volume176
Issue number2
DOIs
StatePublished - Aug 2012

Fingerprint

Hepacivirus
Hepatitis
Allografts
Liver Diseases
Kidney
Failure to Thrive
Virus Diseases
Transaminases
Viral Load
Kidney Transplantation
Sepsis
Tissue Donors
Morbidity
Biopsy
Mortality

Keywords

  • elderly
  • end-stage renal disease
  • HCV
  • hepatitis C
  • infectious diseases
  • kidney transplant

ASJC Scopus subject areas

  • Surgery

Cite this

Flohr, T. R., Bonatti, H., Hranjec, T., Keith, D. S., Lobo, P. I., Kumer, S. C., ... Brayman, K. L. (2012). Elderly recipients of hepatitis c positive renal allografts can quickly develop liver disease. Journal of Surgical Research, 176(2), 629-638. https://doi.org/10.1016/j.jss.2011.10.028

Elderly recipients of hepatitis c positive renal allografts can quickly develop liver disease. / Flohr, Tanya R.; Bonatti, Hugo; Hranjec, Tjasa; Keith, Doug S.; Lobo, Peter I.; Kumer, Sean C.; Schmitt, Timothy M.; Sawyer, Robert G.; Pruett, Timothy L.; Roberts, John P.; Brayman, Kenneth L.

In: Journal of Surgical Research, Vol. 176, No. 2, 08.2012, p. 629-638.

Research output: Contribution to journalArticle

Flohr, TR, Bonatti, H, Hranjec, T, Keith, DS, Lobo, PI, Kumer, SC, Schmitt, TM, Sawyer, RG, Pruett, TL, Roberts, JP & Brayman, KL 2012, 'Elderly recipients of hepatitis c positive renal allografts can quickly develop liver disease', Journal of Surgical Research, vol. 176, no. 2, pp. 629-638. https://doi.org/10.1016/j.jss.2011.10.028
Flohr, Tanya R. ; Bonatti, Hugo ; Hranjec, Tjasa ; Keith, Doug S. ; Lobo, Peter I. ; Kumer, Sean C. ; Schmitt, Timothy M. ; Sawyer, Robert G. ; Pruett, Timothy L. ; Roberts, John P. ; Brayman, Kenneth L. / Elderly recipients of hepatitis c positive renal allografts can quickly develop liver disease. In: Journal of Surgical Research. 2012 ; Vol. 176, No. 2. pp. 629-638.
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