Electrical fingerprinting, 3D profiling and detection of tumor cells with solid-state micropores

Waseem Asghar, Yuan Wan, Azhar Ilyas, Robert Bachoo, Young Tae Kim, Samir M. Iqbal

Research output: Contribution to journalArticle

70 Scopus citations

Abstract

Solid-state micropores can provide direct information of ex vivo or in vitro cell populations. Micropores are used to detect and discriminate cancer cells based on the translocation behavior through micropores. The approach provides rapid detection of cell types based on their size and mechano-physical properties like elasticity, viscosity and stiffness. Use of a single micropore device enables detection of tumor cells from whole blood efficiently, at 70% CTC detection efficiency. The CTCs show characteristic electrical signals which easily distinguish these from other cell types. The approach provides a gentle and inexpensive instrument that can be used for specific blood analysis in a lab-on-a-chip setting. The device does not require any preprocessing of the blood sample, particles/beads attachment, surface functionalization or fluorescent tags and provides quantitative and objective detection of cancer cells. This journal is

Original languageEnglish (US)
Pages (from-to)2345-2352
Number of pages8
JournalLab on a Chip - Miniaturisation for Chemistry and Biology
Volume12
Issue number13
DOIs
Publication statusPublished - Jul 7 2012

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ASJC Scopus subject areas

  • Biochemistry
  • Chemistry(all)
  • Bioengineering
  • Biomedical Engineering

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