Electro-oculographic findings in machado-joseph disease

David M. Dawson, Peter Feudo, Howard H. Zubick, Roger Rosenberg, Hilton Fowler

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

Electro-oculographic recordings (EOG) were made on 26 patients with Machado-Joseph disease or at genetic risk for that disease. All patients with clinically apparent disease (ataxia, dysarthria, spasticity, or ophthalmoparesis) had abnormal eye movements. Defects in caloric response, sinsuoidal tracking, opticokinetic nystagmus (OKN), refixation saccades, and presence of gaze paretic nystagmus were detected in that order of frequency. Fourteen subjects were clinically at risk but had normal neurologic examinations or minor equivocal signs. Nine of the fourteen had abnormal EOG, with sinusoidal tracking, calorics, refixation saccades, OKN, and gaze paretic nystagmus being abnormal in that order. EOG may be useful in early case detection and may contribute to genetic counseling.

Original languageEnglish (US)
Pages (from-to)1272-1276
Number of pages5
JournalNeurology
Volume32
Issue number11
DOIs
StatePublished - Nov 1982

ASJC Scopus subject areas

  • Clinical Neurology

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    Dawson, D. M., Feudo, P., Zubick, H. H., Rosenberg, R., & Fowler, H. (1982). Electro-oculographic findings in machado-joseph disease. Neurology, 32(11), 1272-1276. https://doi.org/10.1212/wnl.32.11.1272