TY - JOUR
T1 - Electro-oculographic findings in machado-joseph disease
AU - Dawson, David M.
AU - Feudo, Peter
AU - Zubick, Howard H.
AU - Rosenberg, Roger
AU - Fowler, Hilton
PY - 1982/11
Y1 - 1982/11
N2 - Electro-oculographic recordings (EOG) were made on 26 patients with Machado-Joseph disease or at genetic risk for that disease. All patients with clinically apparent disease (ataxia, dysarthria, spasticity, or ophthalmoparesis) had abnormal eye movements. Defects in caloric response, sinsuoidal tracking, opticokinetic nystagmus (OKN), refixation saccades, and presence of gaze paretic nystagmus were detected in that order of frequency. Fourteen subjects were clinically at risk but had normal neurologic examinations or minor equivocal signs. Nine of the fourteen had abnormal EOG, with sinusoidal tracking, calorics, refixation saccades, OKN, and gaze paretic nystagmus being abnormal in that order. EOG may be useful in early case detection and may contribute to genetic counseling.
AB - Electro-oculographic recordings (EOG) were made on 26 patients with Machado-Joseph disease or at genetic risk for that disease. All patients with clinically apparent disease (ataxia, dysarthria, spasticity, or ophthalmoparesis) had abnormal eye movements. Defects in caloric response, sinsuoidal tracking, opticokinetic nystagmus (OKN), refixation saccades, and presence of gaze paretic nystagmus were detected in that order of frequency. Fourteen subjects were clinically at risk but had normal neurologic examinations or minor equivocal signs. Nine of the fourteen had abnormal EOG, with sinusoidal tracking, calorics, refixation saccades, OKN, and gaze paretic nystagmus being abnormal in that order. EOG may be useful in early case detection and may contribute to genetic counseling.
UR - http://www.scopus.com/inward/record.url?scp=0020447807&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0020447807&partnerID=8YFLogxK
U2 - 10.1212/wnl.32.11.1272
DO - 10.1212/wnl.32.11.1272
M3 - Article
C2 - 6890162
AN - SCOPUS:0020447807
SN - 0028-3878
VL - 32
SP - 1272
EP - 1276
JO - Neurology
JF - Neurology
IS - 11
ER -