Electrochemical Investigation of the Eu3+/2+ Redox Couple in Complexes with Variable Numbers of Glycinamide and Acetate Pendant Arms

Marianne E. Burnett, Bukola Adebesin, Alexander M. Funk, Zoltan Kovacs, A. Dean Sherry, Levi A. Ekanger, Matthew J. Allen, Kayla N. Green, S. James Ratnakar

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

The Eu3+/2+ redox couple provides a convenient design platform for responsive pO2 sensors for magnetic resonance imaging (MRI). Specifically, the Eu2+ ion provides T1w contrast enhancement under hypoxic conditions in tissues, whereas, under normoxia, the Eu3+ ion can produce contrast from chemical exchange saturation transfer in MRI. The oxidative stability of the Eu3+/2+ redox couple for a series of tetraaza macrocyclic complexes was investigated in this work using cyclic voltammetry. A series of Eu-containing cyclen-based macrocyclic complexes revealed positive shifts in the Eu3+/2+ redox potentials with each replacement of a carboxylate coordinating arm of the ligand scaffold with glycinamide pendant arms. The data obtained reveal that the complex containing four glycinamide coordinating pendant arms has the highest oxidative stability of the series investigated.

Original languageEnglish (US)
Pages (from-to)5001-5005
Number of pages5
JournalEuropean Journal of Inorganic Chemistry
Volume2017
Issue number43
DOIs
StatePublished - Nov 24 2017

Keywords

  • Cyclic voltammetry
  • Imaging agents
  • Lanthanides
  • Redox chemistry

ASJC Scopus subject areas

  • Inorganic Chemistry

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