Electromagnetic detection and real-time DMLC adaptation to target rotation during radiotherapy

Junqing Wu, Dan Ruan, Byungchul Cho, Amit Sawant, Jay Petersen, Laurence J. Newell, Herbert Cattell, Paul J. Keall

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Purpose: Intrafraction rotation of more than 45° and 25° has been observed for lung and prostate tumors, respectively. Such rotation is not routinely adapted to during current radiotherapy, which may compromise tumor dose coverage. The aim of the study was to investigate the geometric and dosimetric performance of an electromagnetically guided real-time dynamic multileaf collimator (DMLC) tracking system to adapt to intrafractional tumor rotation. Materials/Methods: Target rotation was provided by changing the treatment couch angle. The target rotation was measured by a research Calypso system integrated with a real-time DMLC tracking system employed on a Varian linac. The geometric beam-target rotational alignment difference was measured using electronic portal images. The dosimetric accuracy was quantified using a two-dimensional ion chamber array. For each beam, the following five delivery modes were tested: 1) nonrotated target (reference); 2) fixed rotated target with tracking; 3) fixed rotated target without tracking; 4) actively rotating target with tracking; and 5) actively rotating target without tracking. Dosimetric performance of the latter four modes was measured and compared to the reference dose distribution using a 3 mm/3% γ-test. Results: Geometrically, the beam-target rotational alignment difference was 0.3° ± 0.6° for fixed rotation and 0.3° ± 1.3° for active rotation. Dosimetrically, the average failure rate for the γ-test for a fixed rotated target was 11% with tracking and 36% without tracking. The average failure rate for an actively rotating target was 9% with tracking and 35% without tracking. Conclusions: For the first time, real-time target rotation has been accurately detected and adapted to during radiation delivery via DMLC tracking. The beam-target rotational alignment difference was mostly within 1°. Dose distributions to fixed and actively rotating targets with DMLC tracking were significantly superior to those without tracking.

Original languageEnglish (US)
JournalInternational Journal of Radiation Oncology Biology Physics
Volume82
Issue number3
DOIs
StatePublished - Mar 1 2012

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Electromagnetic Phenomena
collimators
radiation therapy
Radiotherapy
electromagnetism
tumors
alignment
Neoplasms
dosage
delivery
Calypso
Prostate
couches
Ions
Radiation
ionization chambers
Lung
lungs
Research

Keywords

  • Intrafraction motion
  • Real-time
  • Tumor rotation
  • Tumor tracking

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Radiation
  • Cancer Research

Cite this

Electromagnetic detection and real-time DMLC adaptation to target rotation during radiotherapy. / Wu, Junqing; Ruan, Dan; Cho, Byungchul; Sawant, Amit; Petersen, Jay; Newell, Laurence J.; Cattell, Herbert; Keall, Paul J.

In: International Journal of Radiation Oncology Biology Physics, Vol. 82, No. 3, 01.03.2012.

Research output: Contribution to journalArticle

Wu, Junqing ; Ruan, Dan ; Cho, Byungchul ; Sawant, Amit ; Petersen, Jay ; Newell, Laurence J. ; Cattell, Herbert ; Keall, Paul J. / Electromagnetic detection and real-time DMLC adaptation to target rotation during radiotherapy. In: International Journal of Radiation Oncology Biology Physics. 2012 ; Vol. 82, No. 3.
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abstract = "Purpose: Intrafraction rotation of more than 45° and 25° has been observed for lung and prostate tumors, respectively. Such rotation is not routinely adapted to during current radiotherapy, which may compromise tumor dose coverage. The aim of the study was to investigate the geometric and dosimetric performance of an electromagnetically guided real-time dynamic multileaf collimator (DMLC) tracking system to adapt to intrafractional tumor rotation. Materials/Methods: Target rotation was provided by changing the treatment couch angle. The target rotation was measured by a research Calypso system integrated with a real-time DMLC tracking system employed on a Varian linac. The geometric beam-target rotational alignment difference was measured using electronic portal images. The dosimetric accuracy was quantified using a two-dimensional ion chamber array. For each beam, the following five delivery modes were tested: 1) nonrotated target (reference); 2) fixed rotated target with tracking; 3) fixed rotated target without tracking; 4) actively rotating target with tracking; and 5) actively rotating target without tracking. Dosimetric performance of the latter four modes was measured and compared to the reference dose distribution using a 3 mm/3{\%} γ-test. Results: Geometrically, the beam-target rotational alignment difference was 0.3° ± 0.6° for fixed rotation and 0.3° ± 1.3° for active rotation. Dosimetrically, the average failure rate for the γ-test for a fixed rotated target was 11{\%} with tracking and 36{\%} without tracking. The average failure rate for an actively rotating target was 9{\%} with tracking and 35{\%} without tracking. Conclusions: For the first time, real-time target rotation has been accurately detected and adapted to during radiation delivery via DMLC tracking. The beam-target rotational alignment difference was mostly within 1°. Dose distributions to fixed and actively rotating targets with DMLC tracking were significantly superior to those without tracking.",
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AU - Wu, Junqing

AU - Ruan, Dan

AU - Cho, Byungchul

AU - Sawant, Amit

AU - Petersen, Jay

AU - Newell, Laurence J.

AU - Cattell, Herbert

AU - Keall, Paul J.

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AB - Purpose: Intrafraction rotation of more than 45° and 25° has been observed for lung and prostate tumors, respectively. Such rotation is not routinely adapted to during current radiotherapy, which may compromise tumor dose coverage. The aim of the study was to investigate the geometric and dosimetric performance of an electromagnetically guided real-time dynamic multileaf collimator (DMLC) tracking system to adapt to intrafractional tumor rotation. Materials/Methods: Target rotation was provided by changing the treatment couch angle. The target rotation was measured by a research Calypso system integrated with a real-time DMLC tracking system employed on a Varian linac. The geometric beam-target rotational alignment difference was measured using electronic portal images. The dosimetric accuracy was quantified using a two-dimensional ion chamber array. For each beam, the following five delivery modes were tested: 1) nonrotated target (reference); 2) fixed rotated target with tracking; 3) fixed rotated target without tracking; 4) actively rotating target with tracking; and 5) actively rotating target without tracking. Dosimetric performance of the latter four modes was measured and compared to the reference dose distribution using a 3 mm/3% γ-test. Results: Geometrically, the beam-target rotational alignment difference was 0.3° ± 0.6° for fixed rotation and 0.3° ± 1.3° for active rotation. Dosimetrically, the average failure rate for the γ-test for a fixed rotated target was 11% with tracking and 36% without tracking. The average failure rate for an actively rotating target was 9% with tracking and 35% without tracking. Conclusions: For the first time, real-time target rotation has been accurately detected and adapted to during radiation delivery via DMLC tracking. The beam-target rotational alignment difference was mostly within 1°. Dose distributions to fixed and actively rotating targets with DMLC tracking were significantly superior to those without tracking.

KW - Intrafraction motion

KW - Real-time

KW - Tumor rotation

KW - Tumor tracking

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