Abstract
Heart failure affects nearly 6 million Americans, with a half-million new cases emerging each year. Whereas up to 50% of heart failure patients die of arrhythmia, the diverse mechanisms underlying heart failure-associated arrhythmia are poorly understood. As a consequence, effectiveness of antiarrhythmic pharmacotherapy remains elusive. Here, we review recent advances in our understanding of heart failure-associated molecular events impacting the electrical function of the myocardium. We approach this from an anatomical standpoint, summarizing recent insights gleaned from pre-clinical models and discussing their relevance to human heart failure.
Original language | English (US) |
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Pages (from-to) | 619-632 |
Number of pages | 14 |
Journal | Journal of Molecular and Cellular Cardiology |
Volume | 48 |
Issue number | 4 |
DOIs | |
State | Published - Apr 2010 |
Keywords
- Arrhythmia
- Electrophysiology
- Heart failure
- Ion channel
- Remodeling
ASJC Scopus subject areas
- Molecular Biology
- Cardiology and Cardiovascular Medicine