Electrophysiological remodeling in heart failure

Yanggan Wang, Joseph A Hill

Research output: Contribution to journalReview articlepeer-review

84 Scopus citations

Abstract

Heart failure affects nearly 6 million Americans, with a half-million new cases emerging each year. Whereas up to 50% of heart failure patients die of arrhythmia, the diverse mechanisms underlying heart failure-associated arrhythmia are poorly understood. As a consequence, effectiveness of antiarrhythmic pharmacotherapy remains elusive. Here, we review recent advances in our understanding of heart failure-associated molecular events impacting the electrical function of the myocardium. We approach this from an anatomical standpoint, summarizing recent insights gleaned from pre-clinical models and discussing their relevance to human heart failure.

Original languageEnglish (US)
Pages (from-to)619-632
Number of pages14
JournalJournal of Molecular and Cellular Cardiology
Volume48
Issue number4
DOIs
StatePublished - Apr 2010

Keywords

  • Arrhythmia
  • Electrophysiology
  • Heart failure
  • Ion channel
  • Remodeling

ASJC Scopus subject areas

  • Molecular Biology
  • Cardiology and Cardiovascular Medicine

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