Electrophysiological signatures of spatial boundaries in the human subiculum

Sang Ah Lee; Jonathan F. Miller; Andrew J. Watrous; Michael Sperling; Ashwini Sharan; Gregory A. Worrell; Brent M. Berry; Barbara C. Jobst; Kathryn A. Davis; Robert E. Gross; Bradley Lega; Sameer Sheth; Sandhitsu R. Das; Joel M. Stein; Richard Gorniak; Daniel S. Rizzuto; Joshua Jacobs

doi:10.1101/218040

Electrophysiological signatures of spatial boundaries in the human subiculum

Sang Ah Lee, Jonathan F. Miller, Andrew J. Watrous, Michael Sperling, Ashwini Sharan, Gregory A. Worrell, Brent M. Berry, Barbara C. Jobst, Kathryn A. Davis, Robert E. Gross, Bradley Lega, Sameer Sheth, Sandhitsu R. Das, Joel M. Stein, Richard Gorniak, Daniel S. Rizzuto, Joshua Jacobs

Research output: Contribution to journal › Article › peer-review

Abstract

Environmental boundaries play a crucial role in spatial navigation and memory across a wide range of distantly-related species. In rodents, boundary representations have been identified at the single-cell level in the subiculum and entorhinal cortex of the hippocampal formation. While studies of hippocampal function and spatial behavior suggest that similar representations might exist in humans, boundary-related neural activity has not been identified electrophysiologically in humans until now. Here we present direct intracranial recordings from the hippocampal formation of surgical epilepsy patients while they performed a virtual spatial navigation task. Our results suggest that encoding target locations near boundaries elicited stronger theta oscillations than for target locations near the center of the environment and that this difference cannot be explained by variables such as trial length, speed, or movement. These findings provide the first direct evidence of boundary-dependent neural activity localized in humans to the subiculum, the homologue of the hippocampal subregion in which most rodent boundary cells are found.

Original language	English (US)
Journal	Unknown Journal
DOIs	https://doi.org/10.1101/218040
State	Published - Nov 12 2017

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)
Agricultural and Biological Sciences(all)
Immunology and Microbiology(all)
Neuroscience(all)
Pharmacology, Toxicology and Pharmaceutics(all)

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Electrophysiological signatures of spatial boundaries in the human subiculum. / Lee, Sang Ah; Miller, Jonathan F.; Watrous, Andrew J.; Sperling, Michael; Sharan, Ashwini; Worrell, Gregory A.; Berry, Brent M.; Jobst, Barbara C.; Davis, Kathryn A.; Gross, Robert E.; Lega, Bradley; Sheth, Sameer; Das, Sandhitsu R.; Stein, Joel M.; Gorniak, Richard; Rizzuto, Daniel S.; Jacobs, Joshua.

In: Unknown Journal, 12.11.2017.

Research output: Contribution to journal › Article › peer-review

Lee, Sang Ah ; Miller, Jonathan F. ; Watrous, Andrew J. ; Sperling, Michael ; Sharan, Ashwini ; Worrell, Gregory A. ; Berry, Brent M. ; Jobst, Barbara C. ; Davis, Kathryn A. ; Gross, Robert E. ; Lega, Bradley ; Sheth, Sameer ; Das, Sandhitsu R. ; Stein, Joel M. ; Gorniak, Richard ; Rizzuto, Daniel S. ; Jacobs, Joshua. / Electrophysiological signatures of spatial boundaries in the human subiculum. In: Unknown Journal. 2017.

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abstract = "Environmental boundaries play a crucial role in spatial navigation and memory across a wide range of distantly-related species. In rodents, boundary representations have been identified at the single-cell level in the subiculum and entorhinal cortex of the hippocampal formation. While studies of hippocampal function and spatial behavior suggest that similar representations might exist in humans, boundary-related neural activity has not been identified electrophysiologically in humans until now. Here we present direct intracranial recordings from the hippocampal formation of surgical epilepsy patients while they performed a virtual spatial navigation task. Our results suggest that encoding target locations near boundaries elicited stronger theta oscillations than for target locations near the center of the environment and that this difference cannot be explained by variables such as trial length, speed, or movement. These findings provide the first direct evidence of boundary-dependent neural activity localized in humans to the subiculum, the homologue of the hippocampal subregion in which most rodent boundary cells are found.",

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AU - Das, Sandhitsu R.

AU - Stein, Joel M.

AU - Gorniak, Richard

AU - Rizzuto, Daniel S.

AU - Jacobs, Joshua

N1 - Publisher Copyright: The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.

PY - 2017/11/12

Y1 - 2017/11/12

N2 - Environmental boundaries play a crucial role in spatial navigation and memory across a wide range of distantly-related species. In rodents, boundary representations have been identified at the single-cell level in the subiculum and entorhinal cortex of the hippocampal formation. While studies of hippocampal function and spatial behavior suggest that similar representations might exist in humans, boundary-related neural activity has not been identified electrophysiologically in humans until now. Here we present direct intracranial recordings from the hippocampal formation of surgical epilepsy patients while they performed a virtual spatial navigation task. Our results suggest that encoding target locations near boundaries elicited stronger theta oscillations than for target locations near the center of the environment and that this difference cannot be explained by variables such as trial length, speed, or movement. These findings provide the first direct evidence of boundary-dependent neural activity localized in humans to the subiculum, the homologue of the hippocampal subregion in which most rodent boundary cells are found.

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