Electrophysiological Studies Support Utility of Positive Modulators of SK Channels for the Treatment of Spinocerebellar Ataxia Type 2

Medicine & Life Sciences

• Spinocerebellar Ataxias 100%
• Purkinje Cells 38%
• Ataxin-2 30%
• Type 2 Episodic Ataxia 19%
• Chlorzoxazone 18%
• Cerebellar Diseases 15%
• 4-(chlorophenyl)-(2-(3,5-dimethylpyrazol-1-yl)-9-methyl-9H-purin-6-yl)amine 13%
• Huntington Disease 12%
• Gain of Function Mutation 7%
• polyglutamine 7%
• Urethane 6%
• Injections 6%
• Loss of Function Mutation 6%
• Mutant Proteins 6%
• Transgenic Mice 5%
• Head 4%
• RNA 3%
• Calcium 3%
• Pharmacology 3%
• Neurons 3%
• Genes 2%
• Therapeutics 0%